Highly enantioselective synthesis of 3-hydroxy-2-phenylpiperidine via the sharpless AD-reaction

被引：21

作者：

Stadler, H ^{[1
]}

Bös, M ^{[1
]}

机构：

[1] F Hoffmann La Roche & Co Ltd, Preclin Res, Div Pharma, CH-4070 Basel, Switzerland

来源：

HETEROCYCLES | 1999年 / 51卷 / 05期

关键词：

D O I：

10.3987/COM-99-8489

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric dihydroxylation (AD) of the silyl enol ether (3) provided after hydrolysis the hydroxy ketone (4). Subsequent hydrogenation yielded the title compound (1) as a diastereomeric mixture. The cis-isomer is an important building block for the synthesis of potent NK1 receptor antagonists.

引用

页码：1067 / 1071

页数：5

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