Atopic Dermatitis: Epidemiology and Pathogenesis Update

被引：51

作者：

Eichenfield, Lawrence F. ^{[1
]}

Ellis, Charles N. ^{[2
]}

Mancini, Anthony J. ^{[3
,4
]}

Paller, Amy S. ^{[3
,4
]}

Simpson, Eric L. ^{[5
]}

机构：

[1] Univ Calif San Diego, Sch Med, Rady Childrens Hosp, San Diego, CA 92123 USA

[2] Univ Michigan, Med Ctr, Dept Dermatol, Ann Arbor, MI 48109 USA

[3] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Ann & Robert H Lurie Childrens Hosp, Div Pediat Dermatol, Chicago, IL USA

[5] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

来源：

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY | 2012年 / 31卷 / 03期

关键词：

atopic dermatitis pathogenesis; barrier defects; epidermal skin barrier; filaggrin gene; RESISTANT STAPHYLOCOCCUS-AUREUS; FILAGGRIN MUTATIONS; PROTEIN FILAGGRIN; GENE; PREVALENCE; CHILDREN; BARRIER; RISK;

D O I：

10.1016/j.sder.2012.07.002

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The prevalence of atopic dermatitis (AD) has increased markedly in the United States over the past 5 decades, with current reports varying from 10% to 20% prevalence in US children, and new diagnoses are estimated at almost 11% per year. Recent research in AD pathophysiology and pathogenesis has demonstrated that AD is associated with epidermal barrier dysfunction and that mutations in the filaggrin gene are implicated in barrier defects. These discoveries hold promise for future breakthroughs in the diagnosis and management of AD. Semin Cutan Med Surg 31(suppl 3):S3-S5 (C) 2012 Published by Elsevier Inc.

引用

页码：S3 / S5

页数：3

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