Mitochondria: master regulators of danger signalling

被引：670

作者：

Galluzzi, Lorenzo ^{[1
,2
]}

Kepp, Oliver ^{[2
,3
]}

Kroemer, Guido ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Univ Paris 05, F-75006 Paris, France

[2] Inst Gustave Roussy, F-94805 Villejuif, France

[3] INSERM, U848, F-94805 Villejuif, France

[4] Univ Paris 11, F-94270 Le Kremlin Bicetre, France

[5] Ctr Rech Cordeliers, F-75006 Paris, France

[6] Hop Europeen Georges Pompidou, AP HP, F-75015 Paris, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 12期

关键词：

RIG-I; CELL-DEATH; INFLAMMATORY RESPONSES; ACTIVATE NEUTROPHILS; ANTIVIRAL RESPONSE; MAVS; AUTOPHAGY; PROTEIN; INTERFERON; DNA;

D O I：

10.1038/nrm3479

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Throughout more than 1.5 billion years of obligate endosymbiotic co-evolution, mitochondria have developed not only the capacity to control distinct molecular cascades leading to cell death but also the ability to sense (and react to) multiple situations of cellular stress, including viral infection. In addition, mitochondria can emit danger signals that alert the cell or the whole organism of perturbations in homeostasis, hence promoting the induction of cell-intrinsic or systemic adaptive responses, respectively. As such, mitochondria can be considered as master regulators of danger signalling.

引用

页码：780 / 788

页数：9

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