Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter

被引：205

作者：

Belgnaoui, S. Mehdi ^{[1
,2
]}

Paz, Suzanne ^{[1
,2
]}

Hiscott, John ^{[1
,3
]}

机构：

[1] Jewish Gen Hosp, Lady Davis Inst, Terry Fox Mol Oncol Grp, Montreal, PQ, Canada

[2] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ, Canada

[3] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL 34987 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 05期

基金：

加拿大健康研究院;

关键词：

INNATE IMMUNE-RESPONSES; E3 UBIQUITIN LIGASE; NF-KAPPA-B; RIG-I; MAMMALIAN-CELLS; PEROXISOMAL FISSION; NEGATIVE REGULATION; PROTEIN; VIRUS; RNA;

D O I：

10.1016/j.coi.2011.08.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein to orchestrate the innate host response to pathogen, ultimately leading to the induction of antiviral and inflammatory responses mediated by type I interferon (IFN) and NF-kappa B pathways. MAVS is localized to the outer mitochondrial membrane, and has been associated with peroxisomes, the endoplasmic reticulum and autophagosomes, where it coordinates signaling events downstream of RLRs. MAVS not only plays a pivotal role in the induction of antiviral and inflammatory pathways but is also involved in the coordination of apoptotic and metabolic functions. This review summarizes recent findings related to the MAVS adapter and its essential role in the innate immune response to RNA viruses.

引用

页码：564 / 572

页数：9

共 54 条

[1] RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate [J].

Ablasser, Andrea ;

Bauernfeind, Franz ;

Hartmann, Gunther ;

Latz, Eicke ;

Fitzgerald, Katherine A. ;

Hornung, Veit .

NATURE IMMUNOLOGY, 2009, 10 (10) :1065-U40

[2] Peroxisomes Are Oxidative Organelles [J].

Antonenkov, Vasily D. ;

Grunau, Silke ;

Ohlmeier, Steffen ;

Hiltunen, J. Kalervo .

ANTIOXIDANTS & REDOX SIGNALING, 2010, 13 (04) :525-537

[3] Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125 [J].

Arimoto, Kei-ichiro ;

Takahashi, Hitoshi ;

Hishiki, Takayuki ;

Konishi, Hicleyuki ;

Fujita, Takashi ;

Shimotohno, Kunitada .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (18) :7500-7505

[4] Organelle dynamics and dysfunction: A closer link between peroxisomes and mitochondria [J].

Camoes, F. ;

Bonekamp, N. A. ;

Delille, H. K. ;

Schrader, M. .

JOURNAL OF INHERITED METABOLIC DISEASE, 2009, 32 (02) :163-180

[5] RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway [J].

Chiu, Yu-Hsin ;

MacMillan, John B. ;

Chen, Zhijian J. .

CELL, 2009, 138 (03) :576-591

[6] Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity [J].

Dixit, Evelyn ;

Boulant, Steeve ;

Zhang, Yijing ;

Lee, Amy S. Y. ;

Odendall, Charlotte ;

Shum, Bennett ;

Hacohen, Nir ;

Chen, Zhijian J. ;

Whelan, Sean P. ;

Fransen, Marc ;

Nibert, Max L. ;

Superti-Furga, Giulio ;

Kagan, Jonathan C. .

CELL, 2010, 141 (04) :668-681

[7] TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity [J].

Gack, Michaela U. ;

Shin, Young C. ;

Joo, Chul-Hyun ;

Urano, Tomohiko ;

Liang, Chengyu ;

Sun, Lijun ;

Takeuchi, Osamu ;

Akira, Shizuo ;

Chen, Zhijian ;

Inoue, Satoshi ;

Jung, Jae U. .

NATURE, 2007, 446 (7138) :916-U2

[8] The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells [J].

Gandre-Babbe, Shilpa ;

van der Bliek, Alexander M. .

MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (06) :2402-2412

[9] How peroxisomes multiply [J].

Hettema, Ewald H. ;

Motley, Alison M. .

JOURNAL OF CELL SCIENCE, 2009, 122 (14) :2331-2336

[10] Targeting IRFs by ubiquitination: regulating antiviral responses [J].

Higgs, Rowan ;

Jefferies, Caroline A. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2008, 36 :453-458

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