Mitochondria in innate immunity

被引：199

作者：

Arnoult, Damien ^{[2
]}

Soares, Fraser ^{[1
]}

Tattoli, Ivan ^{[1
]}

Girardin, Stephen E. ^{[1
]}

机构：

[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada

[2] Hop Paul Brousse, INSERM, U1014, F-94807 Villejuif, France

来源：

EMBO REPORTS | 2011年 / 12卷 / 09期

关键词：

mitochondria; innate immunity; MAVS; pathogen; host metabolism; NLRP3 INFLAMMASOME ACTIVATION; NF-KAPPA-B; RIG-I; ADAPTER PROTEIN; RECEPTOR; MAVS; RECOGNITION; AUTOPHAGY; RESPONSES; NLRX1;

D O I：

10.1038/embor.2011.157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are cellular organelles involved in host-cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS-a crucial adaptor for RIGI-like receptor signalling-as a mitochondria-anchored protein. Recently, other innate immune molecules, such as NLRX1, TRAF6, NLRP3 and IRGM have been functionally associated with mitochondria. Furthermore, mitochondrial alarmins-such as mitochondrial DNA and formyl peptides-can be released by damaged mitochondria and trigger inflammation. Therefore, mitochondria emerge as a fundamental hub for innate immune signalling.

引用

页码：901 / 910

页数：10

共 70 条

[1] Enhancement of Reactive Oxygen Species Production and Chlamydial Infection by the Mitochondrial Nod-like Family Member NLRX1 [J].

Abdul-Sater, Ali A. ;

Said-Sadier, Najwane ;

Lam, Verissa M. ;

Singh, Bhavni ;

Pettengill, Matthew A. ;

Soares, Fraser ;

Tattoli, Ivan ;

Lipinski, Simone ;

Girardin, Stephen E. ;

Rosenstiel, Philip ;

Ojcius, David M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (53) :41637-41645

[2] Toll-like receptor signalling [J].

Akira, S ;

Takeda, K .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511

[3] The role of mitochondria in cellular defense against microbial infection [J].

Arnoult, Damien ;

Carneiro, Leticia ;

Tattoli, Ivan ;

Girardin, Stephen E. .

SEMINARS IN IMMUNOLOGY, 2009, 21 (04) :223-232

[4] An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix [J].

Arnoult, Damien ;

Soares, Fraser ;

Tattoli, Ivan ;

Castanier, Celine ;

Philpott, Dana J. ;

Girardin, Stephen E. .

JOURNAL OF CELL SCIENCE, 2009, 122 (17) :3161-3168

[5] Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses [J].

Barber, Glen N. .

CURRENT OPINION IN IMMUNOLOGY, 2011, 23 (01) :10-20

[6] The microbial and danger signals that activate Nod-like receptors [J].

Benko, Szilvia ;

Philpott, Dana J. ;

Girardin, Stephen E. .

CYTOKINE, 2008, 43 (03) :368-373

[7] Shigella Induces Mitochondrial Dysfunction and Cell Death in Nonmyleoid Cells [J].

Carneiro, Leticia A. M. ;

Travassos, Leonardo H. ;

Soares, Fraser ;

Tattoli, Ivan ;

Magalhaes, Joao G. ;

Bozza, Marcelo T. ;

Plotkowski, Maria C. ;

Sansonetti, Philippe J. ;

Molkentin, Jeffery D. ;

Philpott, Dana J. ;

Girardin, Stephen E. .

CELL HOST & MICROBE, 2009, 5 (02) :123-136

[8] Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway [J].

Castanier, Celine ;

Garcin, Dominique ;

Vazquez, Aime ;

Arnoult, Damien .

EMBO REPORTS, 2010, 11 (02) :133-138

[9] Mitochondria: Dynamic organelles in disease, aging, and development [J].

Chan, David C. .

CELL, 2006, 125 (07) :1241-1252

[10] HIF-1α is essential for myeloid cell-mediated inflammation [J].

Cramer, T ;

Yamanishi, Y ;

Clausen, BE ;

Förster, I ;

Pawlinski, R ;

Mackman, N ;

Haase, VH ;

Jaenisch, R ;

Corr, M ;

Nizet, V ;

Firestein, GS ;

Gerber, HP ;

Ferrara, N ;

Johnson, RS .

CELL, 2003, 112 (05) :645-657

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