Can DCs be distinguished from macrophages by molecular signatures?

被引:57
作者
Hume, David A. [1 ]
Mabbott, Neil [1 ]
Raza, Sobia [1 ]
Freeman, Tom C. [1 ]
机构
[1] Univ Edinburgh, Roslin Inst, Edinburgh, Midlothian, Scotland
基金
英国生物技术与生命科学研究理事会;
关键词
GENE-EXPRESSION; MONOCYTES; TISSUE;
D O I
10.1038/ni.2516
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
引用
收藏
页码:187 / 189
页数:3
相关论文
共 12 条
[1]
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages [J].
Gautier, Emmanuel L. ;
Shay, Tal ;
Miller, Jennifer ;
Greter, Melanie ;
Jakubzick, Claudia ;
Ivanov, Stoyan ;
Helft, Julie ;
Chow, Andrew ;
Elpek, Kutlu G. ;
Gordonov, Simon ;
Mazloom, Amin R. ;
Ma'ayan, Avi ;
Chua, Wei-Jen ;
Hansen, Ted H. ;
Turley, Shannon J. ;
Merad, Miriam ;
Randolph, Gwendalyn J. .
NATURE IMMUNOLOGY, 2012, 13 (11) :1118-1128
[2]
Unravelling mononuclear phagocyte heterogeneity [J].
Geissmann, Frederic ;
Gordon, Siamon ;
Hume, David A. ;
Mowat, Allan M. ;
Randolph, Gwendalyn J. .
NATURE REVIEWS IMMUNOLOGY, 2010, 10 (06) :453-U92
[3]
Development of Monocytes, Macrophages, and Dendritic Cells [J].
Geissmann, Frederic ;
Manz, Markus G. ;
Jung, Steffen ;
Sieweke, Michael H. ;
Merad, Miriam ;
Ley, Klaus .
SCIENCE, 2010, 327 (5966) :656-661
[4]
Differentiation and heterogeneity in the mononuclear phagocyte system [J].
Hume, D. A. .
MUCOSAL IMMUNOLOGY, 2008, 1 (06) :432-441
[5]
Plenary Perspective: The complexity of constitutive and inducible gene expression in mononuclear phagocytes [J].
Hume, David A. .
JOURNAL OF LEUKOCYTE BIOLOGY, 2012, 92 (03) :433-444
[6]
Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity [J].
Hume, David A. .
JOURNAL OF LEUKOCYTE BIOLOGY, 2011, 89 (04) :525-538
[7]
Functional clustering and lineage markers: Insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations [J].
Hume, David A. ;
Summers, Kim M. ;
Raza, Sobia ;
Baillie, J. Kenneth ;
Freeman, Thomas C. .
GENOMICS, 2010, 95 (06) :328-338
[8]
Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations [J].
Mabbott, Neil A. ;
Baillie, J. Kenneth ;
Hume, David A. ;
Freeman, Tom C. .
IMMUNOBIOLOGY, 2010, 215 (9-10) :724-736
[9]
An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation [J].
MacDonald, Kelli P. A. ;
Palmer, James S. ;
Cronau, Stephen ;
Seppanen, Elke ;
Olver, Stuart ;
Raffelt, Neil C. ;
Kuns, Rachel ;
Pettit, Allison R. ;
Clouston, Andrew ;
Wainwright, Brandon ;
Branstetter, Dan ;
Smith, Jeffrey ;
Paxton, Raymond J. ;
Cerretti, Douglas Pat ;
Bonham, Lynn ;
Hill, Geoffrey R. ;
Hume, David A. .
BLOOD, 2010, 116 (19) :3955-3963
[10]
Deciphering the transcriptional network of the dendritic cell lineage [J].
Miller, Jennifer C. ;
Brown, Brian D. ;
Shay, Tal ;
Gautier, Emmanuel L. ;
Jojic, Vladimir ;
Cohain, Ariella ;
Pandey, Gaurav ;
Leboeuf, Marylene ;
Elpek, Kutlu G. ;
Helft, Julie ;
Hashimoto, Daigo ;
Chow, Andrew ;
Price, Jeremy ;
Greter, Melanie ;
Bogunovic, Milena ;
Bellemare-Pelletier, Angelique ;
Frenette, Paul S. ;
Randolph, Gwendalyn J. ;
Turley, Shannon J. ;
Merad, Miriam .
NATURE IMMUNOLOGY, 2012, 13 (09) :888-899