The many roads to cross-presentation

被引：59

作者：

Groothuis, TAM ^{[1
]}

Neefjes, J ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Tumor Biol, NL-1066 CX Amsterdam, Netherlands

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 202卷 / 10期

关键词：

D O I：

10.1084/jem.20051379

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes ( CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system, in which the machinery required for peptide loading of MHC class I molecules is introduced directly into the phagosome. Here, we discuss the evidence for and against the ER-phagosome concept as well as other possible mechanisms of cross-presentation.

引用

页码：1313 / 1318

页数：6

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