mTOR is a key modulator of ageing and age-related disease

被引：1351

作者：

Johnson, Simon C. ^{[1
]}

Rabinovitch, Peter S. ^{[1
]}

Kaeberlein, Matt ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Guangdong Med Coll, Inst Aging Res, Dongguan 523808, Peoples R China

来源：

NATURE | 2013年 / 493卷 / 7432期

基金：

美国国家科学基金会;

关键词：

CHRONOLOGICAL LIFE-SPAN; MAMMALIAN TARGET; DIETARY RESTRICTION; MACULAR DEGENERATION; CARDIAC-HYPERTROPHY; COGNITIVE DEFICITS; STRESS RESISTANCE; MOUSE MODEL; RAPAMYCIN; INHIBITION;

D O I：

10.1038/nature11861

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Many experts in the biology of ageing believe that pharmacological interventions to slow ageing are a matter of 'when' rather than 'if'. A leading target for such interventions is the nutrient response pathway defined by the mechanistic target of rapamycin (mTOR). Inhibition of this pathway extends lifespan in model organisms and confers protection against a growing list of age-related pathologies. Characterized inhibitors of this pathway are already clinically approved, and others are under development. Although adverse side effects currently preclude use in otherwise healthy individuals, drugs that target the mTOR pathway could one day become widely used to slow ageing and reduce age-related pathologies in humans.

引用

页码：338 / 345

页数：8

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