Oxidative Conversion of α,α-Disubstituted Acetamides to Corresponding One-Carbon-Shorter Ketones Using Hypervalent Iodine (λ5) Reagents in Combination with Tetraethylammonium Bromide

被引：39

作者：

Bellale, Eknath V. ^{[1
]}

Bhalerao, Dinesh S. ^{[1
]}

Akamanchi, Krishnacharya G. ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Bombay 400019, Maharashtra, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 23期

关键词：

D O I：

10.1021/jo801580g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha,alpha-Disubstituted acetamides undergo oxidative dehomologation to give one-carbon-shorter ketones when reacted with a hypervalent iodine (lambda(5)) reagent in combination with tetraethylammonium bromide (TEAB) in various solvents. In further studies. one such combination of a hypervalent iodine (lambda(5)) reagent. o-iodoxybenzoic acid, and TEAB has been established as a new, mild, efficient, and general method for the transformation.

引用

页码：9473 / 9475

页数：3

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