Modelling infectious disease - time to think outside the box?

被引:39
作者
Wiles, S
Hanage, WP
Frankel, G
Robertson, B
机构
[1] Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London SW7 2AZ, England
[2] Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Dept Infect Dis Epidemiol, London W2 1PG, England
[3] Univ London Imperial Coll Sci Technol & Med, Fac Med, Ctr Mol Microbiol & Infect, London, England
基金
英国惠康基金;
关键词
D O I
10.1038/nrmicro1386
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Models occupy an essential position in the study of infectious disease as a result of the ethical problems of exposing humans to potentially lethal agents. Deliberately induced infections in well-defined animal models provide much useful information about disease processes in an approximation of their natural context. Despite this, animal models are not the natural disease process, and recent experimental advances show, perhaps not unsurprisingly, that there are large differences between natural infections and animal models. Focusing on mouse models of bacterial pathogens, we discuss some of these discrepancies and suggest ways of improving model systems in the future.
引用
收藏
页码:307 / 312
页数:6
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