Glyceryl trinitrate treatment up-regulates soluble guanylyl cyclase in rat dura mater

被引：10

作者：

Behrends, S

Knyihár-Csillik, E

Kempfert, J

Scholz, H

Csillik, B

Vécsei, L

机构：

[1] Univ Hamburg, Inst Expt & Klin Pharmakol, D-20251 Hamburg, Germany

[2] Univ Szeged, Sch Med, Dept Neurol, H-6701 Szeged, Hungary

[3] Univ Szeged, Sch Med, Dept Anat, H-6701 Szeged, Hungary

来源：

NEUROREPORT | 2001年 / 12卷 / 18期

关键词：

dura mater; glyceryl trinitrate; headache; soluble guanylyl cyclase;

D O I：

10.1097/00001756-200112210-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Nitric oxide (NO) is a key molecule in vascular headaches and the dura mater has been implicated as a tissue where vascular headache develops. Here we demonstrate expression, enzyme activity and cellular distribution of the intracellular receptor for NO, soluble guanylyl cyclase (sGC), in rat dura mater. Subcutaneous treatment of rats with the NO-donor glyceryl trinitrate (GTN) induced an increase of sGC expression and activity in dural blood vessels after 20-30 min. It has previously been shown that GTN induces headache in normal subjects after 20-30 min. Our Findings suggest that an Lip-regulation of the NO target enzyme contributes to the pathogenesis of GTN-induced headache explaining the subacute rather than acute onset of symptoms. NeuroReport 12:3993-3996 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：3993 / 3996

页数：4

共 11 条

[1]

Nitric oxide-induced headache in patients with chronic tension-type headache [J].