Erythropoietin and the nervous system

被引：152

作者：

Genc, S ^{[1
]}

Koroglu, TF

Genc, K

机构：

[1] Dokuz Eylul Univ, Sch Med, Dept Med Biol & Genet, TR-35340 Izmir, Turkey

[2] Dokuz Eylul Univ, Sch Med, Dept Physiol, TR-35340 Izmir, Turkey

[3] Dokuz Eylul Univ, Sch Med, Dept Pediat, TR-35340 Izmir, Turkey

来源：

BRAIN RESEARCH | 2004年 / 1000卷 / 1-2期

关键词：

erythiopoietin; neuroprotection; neurodegeneration; apoptosis; ischemic preconditioning; signal transduction;

D O I：

10.1016/j.brainres.2003.12.037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Erythropoietin (Epo) is a hematopoietic growth factor and cytokine which stimulates erythropoiesis. In recent years, Epo has been shown to have important nonhematopoietic functions in the nervous system. Noncrythropoietic actions of Epo include a critical role in the development. maintenance. protection and repair of the nervous system. A wide variety of experimental Studies have shown that Epo and its receptor are expressed in the nervous system and Epo exerts remarkable neuroprotection in cell culture and animal models of nervous system disorders. In this review we summarize the Current knowledge oil the neurotrophic and neuroprotective properties of Epo, the mechanisms by which Epo produces neuroprotection and the signal transduction systems regulated by Epo in the nervous system. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：19 / 31

页数：13

共 111 条

[31] LOCALIZATION OF SPECIFIC ERYTHROPOIETIN BINDING-SITES IN DEFINED AREAS OF THE MOUSE-BRAIN [J].

DIGICAYLIOGLU, M ;

BICHET, S ;

MARTI, HH ;

WENGER, RH ;

RIVAS, LA ;

BAUER, C ;

GASSMANN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (09) :3717-3720

[32] Ischemic tolerance and endogenous neuroprotection [J].

Dirnagl, U ;

Simon, RP ;

Hallenbeck, JM .

TRENDS IN NEUROSCIENCES, 2003, 26 (05) :248-254

[33] Erythropoietin therapy for acute stroke is both safe and beneficial [J].

Ehrenreich, H ;

Hasselblatt, M ;

Dembowski, C ;

Cepek, L ;

Lewczuk, P ;

Stiefel, M ;

Rustenbeck, HH ;

Breiter, N ;

Jacob, S ;

Knerlich, F ;

Bohn, M ;

Poser, W ;

Rüther, E ;

Kochen, M ;

Gefeller, O ;

Gleiter, C ;

Wessel, TC ;

De Ryck, M ;

Itri, L ;

Prange, H ;

Cerami, A ;

Brines, M ;

Sirén, AL .

MOLECULAR MEDICINE, 2002, 8 (08) :495-505

[34] Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo [J].

Erbayraktar, S ;

Grasso, G ;

Sfacteria, A ;

Xie, QW ;

Coleman, T ;

Kreilgaard, M ;

Torup, L ;

Sager, T ;

Erbayraktar, Z ;

Gokmen, N ;

Yilmaz, O ;

Ghezzi, P ;

Villa, P ;

Fratelli, M ;

Casagrande, S ;

Leist, M ;

Helboe, L ;

Gerwein, J ;

Christensen, S ;

Geist, MA ;

Pedersen, LO ;

Cerami-Hand, C ;

Wuerth, JP ;

Cerami, A ;

Brines, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (11) :6741-6746

[35] Human, nonhuman primate, and rat pancreatic islets express erythropoietin receptors [J].

Fenjves, ES ;

Ochoa, MS ;

Cabrera, O ;

Mendez, AJ ;

Kenyon, NS ;

Inverardi, L ;

Ricordi, C .

TRANSPLANTATION, 2003, 75 (08) :1356-1360

[36] New perspectives on developing acute stroke therapy [J].

Fisher, M ;

Ratan, R .

ANNALS OF NEUROLOGY, 2003, 53 (01) :10-20

[37] Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro [J].

Genc, S ;

Akhisaroglu, M ;

Kuralay, F ;

Genc, K .

NEUROSCIENCE LETTERS, 2002, 321 (1-2) :73-76

[38] Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production [J].

Genc, S ;

Kuralay, F ;

Genc, K ;

Akhisaroglu, M ;

Fadiloglu, S ;

Yorukoglu, K ;

Fadiloglu, M ;

Gure, A .

NEUROSCIENCE LETTERS, 2001, 298 (02) :139-141

[39] Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma [J].

Gorio, A ;

Gokmen, N ;

Erbayraktar, S ;

Yilmaz, O ;

Madaschi, L ;

Cichetti, C ;

Di Giulio, AM ;

Vardar, E ;

Cerami, A ;

Brines, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (14) :9450-9455

[40] Beneficial effects of systemic administration of recombinant human erythropoietin in rabbits subjected to subarachnoid hemorrhage [J].

Grasso, G ;

Buemi, M ;

Alafaci, C ;

Sfacteria, A ;

Passalacqua, M ;

Sturiale, A ;

Calapai, G ;

De Vico, G ;

Piedimonte, G ;

Salpietro, FM ;

Tomasello, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5627-5631

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