A comparison of viral RNA-dependent RNA polymerases

被引：184

作者：

Ferrer-Orta, C

Arias, A

Escarmís, C

Verdaguer, N

机构：

[1] CSIC, Inst Biol Mol Barcelona, E-08028 Barcelona, Spain

[2] CSIC UAM, Ctr Biol Mol, E-28049 Madrid, Spain

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2006年 / 16卷 / 01期

关键词：

D O I：

10.1016/j.sbi.2005.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome replication in picornaviruses is catalyzed by a virally encoded RNA-dependent RNA polymerase, termed 3D. These viruses also use a small protein primer, named VPg, to initiate RNA replication. The recent explosion of structural information on picornaviral 3D polymerases has provided insights into the initiation of RNA synthesis and chain elongation. Comparing these data with results from previous structural analyses of viral RNA-dependent RNA polymerases that catalyze de novo RNA synthesis sheds light on the different strategies that these viruses use to initiate replication.

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页码：27 / 34

页数：8

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