Palladium-Catalyzed Direct Arylation of Nitro-Substituted Aromatics with Aryl Halides

被引：126

作者：

Caron, Laurence ^{[1
]}

Campeau, Louis-Charles ^{[1
]}

Fagnou, Keith ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 20期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1021/ol801839w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct arylation reactions of nitrobenzenes and aryl halides occur in good yield and high ortho regioselectivity. These reactions can be performed on gram scale with as few as 3 equiv of the nitro arene relative to the aryl halide. The synthetic utility of this method is demonstrated via rapid synthesis of a Boscalid intermediate.

引用

页码：4533 / 4536

页数：4

共 66 条

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