Enzyme-Responsive Nanoparticle Systems

被引：137

作者：

Ghadiali, James E. ^{[1
,2
]}

Stevens, Molly M. ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Mat, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Inst Biomed Engn, London SW7 2AZ, England

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 22期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1002/adma.200703158

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inorganic nanoparticles and their accompanying diverse physical properties are now virtually in routine use as imaging tools in cell-biology. In addition to serving as excellent contrast agents, theirsize-and environment-dependent optical and magnetic properties can be harnessed to create enzyme biosensor devices of extremely high sensitivity, whilst circumventing the numerous technical limitations associated with traditional enzyme assays. In this Research News article we discuss recent advances infield of enzyme-responsive nanoparticle systems, where the activity of an enzyme elicits a specific response in the nanoparticle assembly to produce a signal relating to enzyme activity, focusing on three important systems: DNA-structured nanoparticles, protein kinases and proteases.

引用

页码：4359 / 4363

页数：5

共 35 条

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