Testing the nonrandomness of chromosomal breakpoints using highest observed breakages

被引：9

作者：

Hou, CD

Chiang, JT

Tai, JJ

机构：

[1] Natl Taiwan Univ, Inst Epidemiol, Sect 1, Taipei 100, Taiwan

[2] Fu Jen Catholic Univ, Dept Stat, Taipei, Taiwan

[3] Natl Chengchi Univ, Dept Stat, Taipei, Taiwan

来源：

HUMAN GENETICS | 1999年 / 104卷 / 04期

关键词：

D O I：

10.1007/s004390050965

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To determine whether a chromosomal band is a fragile site rather than a spontaneous breakpoint, an essential step is to test the nonrandomness of breakage at the region. In this paper, the nonapplicability of the testing procedure introduced by Bohm et al. is discussed, and a new detection procedure is proposed. This new procedure considers the relations of one site with the others, and can be applied to tests of the nonrandomness of breakpoints under either the proportional probability model, or the equiprobability model. A data set for Chinese patients with colorectal carcinoma is analyzed as an illustration of the proposed method.

引用

页码：350 / 355

页数：6

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