A total synthesis of spiruchostatin A

被引：56

作者：

Doi, T

Iijima, Y

Kazuo, SY

Ganesan, A

Takahashi, T

机构：

[1] Tokyo Inst Technol, Dept Appl Chem, Meguro Ku, Tokyo 1528552, Japan

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[3] Natl Inst Adv Ind Sci & Technol, BIRC, Prot Network Team, Low MW Chem Lab,Kota Ku, Tokyo 1350064, Japan

[4] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 07期

关键词：

spiruchostatin; cyclic depsipeptide; natural product synthesis; asymmetric aldol reaction;

D O I：

10.1016/j.tetlet.2005.12.031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We achieved the total synthesis of the histone deacetylase inhibitor spiruchostatin A, as the prelude to the preparation of a combinatorial library of its analogues. Two key reactions were an asymmetric acetate aldol reaction using a Zr-enolate and macrolactonization Using the Shiina method. (c) 2005 Published by Elsevier Ltd.

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收藏

页码：1177 / 1180

页数：4

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