Ring enhancement in ultrasmall superparamagnetic iron oxide MR imaging: A potential new sign for characterization of liver lesions

被引:51
作者
Mergo, PJ [1 ]
Helmberger, T [1 ]
Nicolas, AI [1 ]
Ros, PR [1 ]
机构
[1] UNIV MUNICH,KLINIKUM GROSSHADERN,INST DIAGNOST RADIOL,W-8000 MUNICH,GERMANY
关键词
D O I
10.2214/ajr.166.2.8553952
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
OBJECTIVE. We performed this study to evaluate the incidence and significance of ring enhancement after IV administration of an ultrasmall superparamagnetic iron oxide (USPIO) particle (Code 7227), a reticuloendothelial contrast agent with potential use as a blood-pool agent, for characterizing focal hepatic lesions. SUBJECTS AND METHODS. Conventional T1-weighted imaging, fat-suppressed T1-weighted imaging, conventional TS-weighted imaging, and fast TP-weighted imaging of the liver were obtained in 27 patients with 43 liver lesions before and after IV administration of a USPIO preparation. All lesions were larger than 1 cm; 29 were malignant and 14 were benign, Diagnosis was confirmed in all cases, either pathologically (19 patients) or by follow-up examination (eight patients). Two readers independently evaluated each pulse sequence for the presence of ring enhancement of hepatic lesions. RESULTS. Ring enhancement was noted only on T1-weighted images, with no ring enhancement evident on T2-weighted images, Twenty of 43 (47%) lesions showed ring enhancement, including 18 of 29 (62%) malignant lesions and two of 14(14%) benign lesions (p < .011; Wilcoxon signed rank test). Fat-suppressed T1-weighted imaging showed ring enhancement better than or equal to conventional T1-weighted imaging in all cases, with ring enhancement of 15 of 18(83%) malignant lesions and two of two benign lesions better demonstrated on fat-suppressed T1-weighted imaging sequences (p less than or equal to .025). CONCLUSION. Ring enhancement after IV administration of Code 7227 is a frequent finding seen more often with malignant than benign lesions, potentially identifying a new MR imaging feature for the characterization of liver lesions. The identification of ring enhancement on T1-weighted images attests to the significant blood-pool effects of USPIO particles.
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页码:379 / 384
页数:6
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