Translational recoding in archaea

被引:24
作者
Cobucci-Ponzano, Beatrice [1 ]
Rossi, Mose [1 ]
Moracci, Marco [1 ]
机构
[1] CNR, Inst Prot Biochem, I-80131 Naples, Italy
关键词
Programmed frameshifting; Stop codon readthrough; Gene expression; Hyperthermophiles; Pseudogenes; ALPHA-L-FUCOSIDASE; TRANSFER-RNA SYNTHETASE; FORMATE DEHYDROGENASE; SULFOLOBUS-SOLFATARICUS; SELENOPROTEIN SYNTHESIS; METHANOSARCINA-BARKERI; METHANOCOCCUS-VOLTAE; PYRROLYSINE ANALOG; GENETIC-CODE; ACTIVE-SITE;
D O I
10.1007/s00792-012-0482-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Translational recoding includes a group of events occurring during gene translation, namely stop codon readthrough, programmed +/- 1 frameshifting, and ribosome bypassing, which have been found in organisms from all domains of life. They serve to regulate protein expression at translational level and represent a relatively less known exception to the traditional central 'dogma' of biology that information flows as DNA -> RNA -> protein and that it is stored in a co-linear way between the 5'-> 3' of nucleic acids and N -> C-terminal of polypeptides. In archaea, in which translational recoding regulates the decoding of the 21st and the 22nd amino acids selenocysteine and pyrrolysine, respectively, only one case of programmed -1 frameshifting has been reported so far and further examples, although promising, have not been confirmed yet. We here summarize the current state-of-the-art of this field that, especially in archaea, has relevant implications for the physiology of life in extreme environments and for the origin of life.
引用
收藏
页码:793 / 803
页数:11
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