Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis

被引：135

作者：

Fang, Zhengyu ^{[1
]}

Wu, Lamei ^{[1
]}

Wang, Luo ^{[1
]}

Yang, Yang ^{[1
]}

Meng, Yusheng ^{[1
]}

Yang, Hongyu ^{[1
]}

机构：

[1] Peking Univ, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong Provi, Peoples R China

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2014年 / 117卷 / 01期

关键词：

ORAL-CAVITY; RELEVANCE;

D O I：

10.1016/j.oooo.2013.09.007

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. The aim of this study was to examine the expression of several cancer-related long non-coding RNAs (lncRNAs) in patients with tongue squamous cell carcinoma (TSCC) and to explore its clinical significance. Study Design. A total of 94 TSCC tissue specimens and matched adjacent normal tissue specimens were collected from patients undergoing surgery for TSCC. Differences in the expression of cancer-related lncRNAs were examined via quantitative reverse transcriptase polymerase chain reaction. WST-1 assay and transwell migration assay were carried out to estimate the proliferation and migration abilities of TSCC cells with different expression levels of urothelial cancer-associated 1 (UCA1) lncRNA. Results. The expression levels of lncRNA UCA1 were significantly elevated in TSCC tissues (P < .0001) and were statistically correlated with lymph node metastasis (P = .0371). Over-expression of UCA1 lncRNA could promote metastatic but not proliferation ability of TSCC cells. Conclusions. Expression of UCA1 lncRNA was enhanced in TSCCs and may play a role in tumor metastasis.

引用

页码：89 / 95

页数：7

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