Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity

被引:298
作者
Lee, Mi-Jeong [1 ]
Pramyothin, Pornpoj [1 ,2 ]
Karastergiou, Kalypso [1 ]
Fried, Susan K. [1 ]
机构
[1] Boston Univ, Sch Med, Sect Endocrinol Diabet & Nutr, Dept Med, Boston, MA 02118 USA
[2] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Med, Bangkok 10700, Thailand
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2014年 / 1842卷 / 03期
关键词
Cortisol; Inflammation; Adipokine; Lipogenesis; Lipolysis; 11-beta hydroxysteroid dehydrogenase; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; PITUITARY-ADRENAL AXIS; INDUCED CORTISOL SECRETION; INDUCED INSULIN-RESISTANCE; BODY-FAT DISTRIBUTION; DE-NOVO LIPOGENESIS; SUBCUTANEOUS ADIPOSE; MINERALOCORTICOID RECEPTOR; LIPOPROTEIN-LIPASE; GROWTH-HORMONE;
D O I
10.1016/j.bbadis.2013.05.029
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Central obesity is associated with insulin resistance and dyslipidemia. Thus, the mechanisms that control fat distribution and its impact on systemic metabolism have importance for understanding the risk for diabetes and cardiovascular disease. Hypercortisolemia at the systemic (Cushing's syndrome) or local levels (due to adipose-specific overproduction via 11 beta-hydroxysteroid dehydrogenase 1) results in the preferential expansion of central, especially visceral fat depots. At the same time, peripheral subcutaneous depots can become depleted. The biochemical and molecular mechanisms underlying the depot-specific actions of glucocorticoids (GCs) on adipose tissue function remain poorly understood. GCs exert pleiotropic effects on adipocyte metabolic, endocrine and immune functions, and dampen adipose tissue inflammation. GCs also regulate multiple steps in the process of adipogenesis. Acting synergistically with insulin, GCs increase the expression of numerous genes involved in fat deposition. Variable effects of GC on lipolysis are reported, and GC can improve or impair insulin action depending on the experimental conditions. Thus, the net effect of GC on fat storage appears to depend on the physiologic context. The preferential effects of GC on visceral adipose tissue have been linked to higher cortisol production and glucocorticoid receptor expression, but the molecular details of the depot-dependent actions of GCs are only beginning to be understood. In addition, increasing evidence underlines the importance of circadian variations in GCs in relationship to the timing of meals for determining their anabolic actions on the adipocyte. In summary, although the molecular mechanisms remain to be fully elucidated, there is increasing evidence that GCs have multiple, depot-dependent effects on adipocyte gene expression and metabolism that promote central fat deposition. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:473 / 481
页数:9
相关论文
共 127 条
[81]
Obesity in mice with adipocyte-specific deletion of clock component Arntl [J].
Paschos, Georgios K. ;
Ibrahim, Salam ;
Song, Wen-Liang ;
Kunieda, Takeshige ;
Grant, Gregory ;
Reyes, Teresa M. ;
Bradfield, Christopher A. ;
Vaughan, Cheryl H. ;
Eiden, Michael ;
Masoodi, Mojgan ;
Griffin, Julian L. ;
Wang, Fenfen ;
Lawson, John A. ;
FitzGerald, Garret A. .
NATURE MEDICINE, 2012, 18 (12) :1768-+
[82]
THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN OBESE WOMEN WITH DIFFERENT PATTERNS OF BODY-FAT DISTRIBUTION [J].
PASQUALI, R ;
CANTOBELLI, S ;
CASIMIRRI, F ;
CAPELLI, M ;
BORTOLUZZI, L ;
FLAMIA, R ;
LABATE, AMM ;
BARBARA, L .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (02) :341-346
[83]
Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: A dose-response study [J].
Pasquali, R ;
Ambrosi, B ;
Armanini, D ;
Cavagnini, F ;
Uberti, ED ;
del Rio, G ;
de Pergola, G ;
Maccario, M ;
Mantero, F ;
Marugo, M ;
Rotella, CM ;
Vettor, R .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (01) :166-175
[84]
Glucocorticoids and Thiazolidinediones Interfere with Adipocyte-mediated Macrophage Chemotaxis and Recruitment [J].
Patsouris, David ;
Neels, Jaap G. ;
Fan, WuQiang ;
Li, Ping-Ping ;
Nguyen, M. T. Audrey ;
Olefsky, Jerrold M. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (45) :31223-31235
[85]
The effects of glucocorticoids on adipose tissue lipid metabolism [J].
Peckett, Ashley J. ;
Wright, David C. ;
Riddell, Michael C. .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2011, 60 (11) :1500-1510
[86]
CHARACTERIZATION OF REGIONAL AND GENDER DIFFERENCES IN GLUCOCORTICOID RECEPTORS AND LIPOPROTEIN-LIPASE ACTIVITY IN HUMAN ADIPOSE-TISSUE [J].
PEDERSEN, SB ;
JONLER, M ;
RICHELSEN, B .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (06) :1354-1359
[87]
A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells [J].
Polman, J. Annelies E. ;
Welten, Jennifer E. ;
Bosch, Danny S. ;
de Jonge, Robert T. ;
Balog, Judit ;
van der Maarel, Silvere M. ;
de Kloet, E. Ronald ;
Datson, Nicole A. .
BMC NEUROSCIENCE, 2012, 13
[88]
Tissue-specific changes in peripheral cortisol metabolism in obese women:: Increased adipose 11β-hydroxysteroid dehydrogenase type 1 activity [J].
Rask, E ;
Walker, BR ;
Söderberg, S ;
Livingstone, DEW ;
Eliasson, M ;
Johnson, O ;
Andrew, R ;
Olsson, T .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (07) :3330-3336
[89]
The Implication of Brown Adipose Tissue for Humans [J].
Ravussin, Eric ;
Galgani, Jose E. .
ANNUAL REVIEW OF NUTRITION, VOL 31, 2011, 31 :33-47
[90]
MUSCLE AND ADIPOSE-TISSUE MORPHOLOGY AND METABOLISM IN CUSHINGS-SYNDROME [J].
REBUFFESCRIVE, M ;
KROTKIEWSKI, M ;
ELFVERSON, J ;
BJORNTORP, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 67 (06) :1122-1128