Facile and purification free synthesis of peptides utilizing ROMPgel- and ROMPsphere-supported coupling reagents

被引：15

作者：

Barrett, AGM ^{[1
]}

Bibal, B ^{[1
]}

Hopkins, BT ^{[1
]}

Köbberling, J ^{[1
]}

Love, AC ^{[1
]}

Tedeschi, L ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

TETRAHEDRON | 2005年 / 61卷 / 51期

基金：

英国工程与自然科学研究理事会;

关键词：

acylations; combinatorial chemistry; peptides; parallel synthesis; supported reagents;

D O I：

10.1016/j.tet.2005.06.120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Norbomene-2-carboxaldehyde and norbornadiene were respectively converted into norbornene derivatives functionalized with fluoroformamidinium hexafluorophosphate and 2-bromo-N-methylpyridinium tetrafluoroborate residues. Both these norbomene monomers were ring opening metathesis polymerized or graft copolymerized onto polystyrene cores to produce ROMPgel and ROMPsphere peptide-coupling reagents. These were used to prepare hindered amides, dipeptides and tripeptides with minimal purification in parallel arrays. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：12033 / 12041

页数：9

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