Loading of gold nanoparticles inside the DPPC bilayers of liposome and their effects on membrane fluidities

被引：143

作者：

Park, SH

Oh, SG ^{[1
]}

Mun, JY

Han, SS

机构：

[1] Hanyang Univ, Dept Chem Engn, Seoul 113791, South Korea

[2] Korea Univ, Sch Life Sci & Biotechnol, Seoul 136701, South Korea

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2006年 / 48卷 / 02期

关键词：

liposomes; gold nanoparticle; bilayer; membrane fluidity;

D O I：

10.1016/j.colsurfb.2006.01.006

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Gold nanoparticles were loaded in the bilayer of dipalmitoylphosphatidylcholine (DPPC) liposomes, named as gold-loaded liposomes. Above the gel to liquid-crystalline phase transition temperature, membrane fluidities of DPPC liposomes were changed by loading the gold nanoparticles. Compared with liposomes without loading the gold nanoparticles, gold-loaded liposomes showed the lower fluorescence anisotropy values. That is, the membrane fluidities of DPPC bilayer were increased by loading the gold nanoparticles. The membrane fluidities were increased as the amount of gold nanoparticles increased. The existence of gold nanoparticles in the DPPC bilayer was observed by transmission electron microscopy. Through the energy dispersive X-ray spectrometer, the particles in DPPC bilayer were confirmed to be gold nanoparticles. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：112 / 118

页数：7

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