Molecular epidemiology of dengue virus serotypes 2 and 3 in Paraguay during 2001-2006: The association of viral clade introductions with shifting serotype dominance

被引：28

作者：

Aquino, Jose D. J. Diaz ^{[1
]}

Tang, Wei-Feng ^{[1
]}

Ishii, Ryoichi ^{[1
]}

Ono, Tetsuro ^{[2
]}

Eshita, Yuki ^{[1
]}

Aono, Hiroshi ^{[1
]}

Makino, Yoshihiro ^{[1
]}

机构：

[1] Oita Univ, Dept Infect Dis, Fac Med, Oita 8795593, Japan

[2] Minist Salud Publ & Bienestar Social, Lab Cent Salud Publ, Asuncion, Paraguay

来源：

VIRUS RESEARCH | 2008年 / 137卷 / 02期

关键词：

Dengue virus; Envelope gene; Clade; Molecular epidemiology; Paraguay;

D O I：

10.1016/j.virusres.2008.07.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To determine the genetic variability of dengue viruses (DENVs) in Paraguay, the complete envelope gene was sequenced for 4 DENV-2 and 22 DENV-3 strains isolated from 2001 to 2006. The sequence data were used in Bayesian phylogenetic analyses, which revealed that Paraguayan DENV-2 strains fell into two distinct clades within the American/Asian genotype, thus suggesting that the introduction of a new DENV-2 clade was likely associated with the shift of dominant serotype from DENV-3 to DENV-2 in 2005 and might have caused an outbreak of DENV-2. This study also indicated that DENV-3 strains fell into genotype III, of which, several 2006 isolates varied from the remaining isolates in their tree locations. The introduction of this new clade was likely associated with the shift of dominant serotype from DENV-2 to DENV-3 in 2006 and might have caused an epidemic of DENV-3. More data are needed to test this hypothesis. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：266 / 270

页数：5

共 35 条

[1] Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok [J].

Adams, B. ;

Holmes, E. C. ;

Zhang, C. ;

Mammen, M. P., Jr. ;

Nimmannitya, S. ;

Kalayanarooj, S. ;

Boots, M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14234-14239

[2]

[Anonymous], 1995, JAMA, V273, P840

[3] Nucleotide sequence and phylogenetic analyses of dengue type 2 virus isolated in the Dominican Republic [J].

Anzai, S ;

Fukuda, M ;

Otsuka, Y ;

Eshita, Y .

VIRUS GENES, 2004, 29 (02) :219-227

[4] Molecular epidemiology of dengue type 3 virus in Brazil and Paraguay, 2002-2004 [J].

Aquino, Victor H. ;

Anatriello, Elen ;

Goncalves, Paula F. ;

da Silva, Eliana V. ;

Vasconcelos, Pedro F. C. ;

Vieira, Deusylene S. ;

Batista, Weber C. ;

Bobadilla, Maria L. ;

Vazquez, Cynthia ;

Moran, Mirian ;

Figueiredo, Luiz T. M. .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2006, 75 (04) :710-715

[5] Complete coding sequences of dengue-1 viruses from Paraguay and Argentina [J].

Avilés, G ;

Meissner, J ;

Mantovani, R ;

St Jeor, S .

VIRUS RESEARCH, 2003, 98 (01) :75-82

[6] Phylogenetic relationships of dengue-1 viruses from Argentina and Paraguay [J].

Avilés, G ;

Rowe, J ;

Meissner, J ;

Caffarena, JCM ;

Enria, D ;

St Jeor, S .

ARCHIVES OF VIROLOGY, 2002, 147 (11) :2075-2087

[7] Molecular evolution of dengue 2 virus in Puerto Rico: positive selection in the viral envelope accompanies clade reintroduction [J].

Bennett, SN ;

Holmes, EC ;

Chirivella, M ;

Rodriguez, DM ;

Beltran, M ;

Vorndam, V ;

Gubler, DJ ;

McMillan, WO .

JOURNAL OF GENERAL VIROLOGY, 2006, 87 :885-893

[8] Dengue virus circulation and evolution in Mexico:: A phylogenetic perspective [J].

Diaz, Francisco J. ;

Black, William C. ;

Farfan-Ale, Jose A. ;

Lorono-Pino, Maria A. ;

Olson, Kenneth E. ;

Beaty, Barry J. .

ARCHIVES OF MEDICAL RESEARCH, 2006, 37 (06) :760-773

[9] Phylogeography and molecular evolution of dengue 2 in the Caribbean basin, 1981-2000 [J].

Foster, JE ;

Bennett, SN ;

Carrington, CVF ;

Vaughan, H ;

McMillan, WO .

VIROLOGY, 2004, 324 (01) :48-59

[10] Dengue and dengue hemorrhagic fever [J].

Gubler, DJ .

CLINICAL MICROBIOLOGY REVIEWS, 1998, 11 (03) :480-+

← 1 2 3 4 →