Biomarkers in acute heart failure-state of the art

被引:53
作者
Maisel, Alan S. [1 ]
Choudhary, Rajiv [1 ]
机构
[1] San Diego Vet Affairs Med Ctr, Div Cardiol, Dept Med, San Diego, CA 92161 USA
关键词
ACUTE KIDNEY INJURY; GELATINASE-ASSOCIATED LIPOCALIN; RECEPTOR FAMILY-MEMBER; TERMINAL PROVASOPRESSIN COPEPTIN; LEFT-VENTRICULAR DYSFUNCTION; REGIONAL PRO-ADRENOMEDULLIN; B-NATRIURETIC PEPTIDE; SURFACTANT PROTEIN-A; SENSITIVE TROPONIN-T; ACUTE RENAL INJURY;
D O I
10.1038/nrcardio.2012.60
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The role of biomarkers in the management of patients with acute heart failure (HF) has evolved rapidly in the past several years. Representing a major burden on health systems, acute HF has increased the need for earlier diagnosis, better risk stratification, and cost-effective treatment to reduce rates of hospitalization. Biomarker-guided diagnosis and treatment have become essential, especially in the acute setting to which the majority of the patients with acute HF initially present. Studies clearly demonstrate the complexity of these patients, who commonly have multiple comorbidities necessitating an integrative approach. Several groundbreaking studies conducted in the past decade have demonstrated how biomarkers, individually or in combination, can outperform conventional laboratory tests used in the emergency department as well as in hospitalized patients with acute HF. In this Review, we will provide an update on biomarkers considered state of the art in the diagnosis and management of patients with acute HF.
引用
收藏
页码:478 / 490
页数:13
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