Both p140(trk) and p75(NGFR) nerve growth factor receptors mediate nerve growth factor-stimulated calcium uptake

被引：28

作者：

Jiang, H

StUlme, D

Dickens, G

Chabuk, A

Lavarreda, M

Lazarovici, P

Guroff, G

机构：

[1] NICHHD,GROWTH FACTORS SECT,NIH,BETHESDA,MD 20892

[2] HEBREW UNIV JERUSALEM,FAC MED,SCH PHARM,DEPT PHARMACOL,IL-91010 JERUSALEM,ISRAEL

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1997年 / 272卷 / 11期

关键词：

D O I：

10.1074/jbc.272.11.6835

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human p140(trk) and p75(NGFR) were transfected separately into 3T3 cells. Nerve growth factor stimulates calcium uptake into both transfectants but not into untransfected 3T3 cells. p140(trk) cells were stimulated maximally by 25 ng/ml; 100 ng/ml was submaximal for p75(NGFR) cells. K-252a inhibits the effect of NGF on p140(trk) cells but not on p75(NGFR) cells; brain-derived neurotrophic factor stimulates calcium uptake in p75(NGFR) cells but not in p140(trk) cells. The data suggest that both nerve growth factor receptors could be involved in the nerve growth factor-mediated actions of calcium on its target cells: neuronal survival, neuronal protection, and synaptic plasticity.

引用

收藏

页码：6835 / 6837

页数：3

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