Molecular mechanism of the metallothionein gene expression mediated by metal-responsive transcription factor 1

被引：19

作者：

Otsuka, F ^{[1
]}

机构：

[1] Teikyo Univ, Fac Pharmaceut Sci, Dept Toxicol & Environm Hlth, Sagamiko, Kanagawa 1990195, Japan

来源：

JOURNAL OF HEALTH SCIENCE | 2001年 / 47卷 / 06期

关键词：

metallothionein; metal-responsive element; MTF-1; heavy metal; transcription;

D O I：

10.1248/jhs.47.513

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Metal-responsive transcription factor 1 (MTF-1) is essential for activating transcription of the metallothionein genes in response to multiple species of heavy metals by binding to the metal-responsive element (MRE) located in the upstream region of the genes. In contrast, MTF-1 binding to the MRE in vitro is induced only by zinc ions, suggesting that MTF-1 acts as a zinc sensor protein. Although the mechanism allowing such a zinc-responsive factor to respond to various metal species in vivo remains ambiguous, recent information regarding the metal response of MTF-1 and the genes expressed downstream of MTF-1 provides important clues to unraveling the intrinsic mechanism and the biological significance of the MTF-1 functions in vivo.

引用

页码：513 / 519

页数：7

共 47 条

[21]

Koizumi S, 2000, J CELL PHYSIOL, V185, P464, DOI 10.1002/1097-4652(200012)185:3<464::AID-JCP18>3.0.CO

[22]

2-4

[23] Transcriptional activity and regulatory protein binding of metal-responsive elements of the human metallothionein-IIA gene [J].

Koizumi, S ;

Suzuki, K ;

Ogra, Y ;

Yamada, H ;

Otsuka, F .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 259 (03) :635-642

[24] ZINC-SPECIFIC ACTIVATION OF A HELA-CELL NUCLEAR-PROTEIN WHICH INTERACTS WITH A METAL RESPONSIVE ELEMENT OF THE HUMAN METALLOTHIONEIN-IIA GENE [J].

KOIZUMI, S ;

YAMADA, H ;

SUZUKI, K ;

OTSUKA, F .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 210 (02) :555-560

[25] NUCLEAR PROTEINS BINDING TO THE HUMAN METALLOTHIONEIN-IIA GENE UPSTREAM SEQUENCES [J].

KOIZUMI, S ;

OTSUKA, F .

INDUSTRIAL HEALTH, 1994, 32 (04) :193-205

[26]

KOIZUMI S, 1994, METALLOTHIONEIN, V3, P457

[27] The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene [J].

Langmade, SJ ;

Ravindra, R ;

Daniels, PJ ;

Andrews, GK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (44) :34803-34809

[28] Characterization of the mouse metal-regulatory-element-binding proteins, metal element protein-1 and metal regulatory transcription factor-1 [J].

LaRochelle, O ;

Stewart, G ;

Moffatt, P ;

Tremblay, V ;

Séguin, C .

BIOCHEMICAL JOURNAL, 2001, 353 :591-601

[29] Participation of upstream stimulator factor (USF) in cadmium-induction of the mouse metallothionein-I gene [J].

Li, QW ;

Hu, NM ;

Daggett, MAF ;

Chu, WA ;

Bittel, D ;

Johnson, JA ;

Andrews, GK .

NUCLEIC ACIDS RESEARCH, 1998, 26 (22) :5182-5189

[30] Target gene search for the metal-responsive transcription factor MTF-1 [J].

Lichtlen, P ;

Wang, Y ;

Belser, T ;

Georgiev, O ;

Certa, U ;

Sack, R ;

Schaffner, W .

NUCLEIC ACIDS RESEARCH, 2001, 29 (07) :1514-1523

← 1 2 3 4 5 →