Molecular mechanism of the metallothionein gene expression mediated by metal-responsive transcription factor 1

被引：19

作者：

Otsuka, F ^{[1
]}

机构：

[1] Teikyo Univ, Fac Pharmaceut Sci, Dept Toxicol & Environm Hlth, Sagamiko, Kanagawa 1990195, Japan

来源：

JOURNAL OF HEALTH SCIENCE | 2001年 / 47卷 / 06期

关键词：

metallothionein; metal-responsive element; MTF-1; heavy metal; transcription;

D O I：

10.1248/jhs.47.513

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Metal-responsive transcription factor 1 (MTF-1) is essential for activating transcription of the metallothionein genes in response to multiple species of heavy metals by binding to the metal-responsive element (MRE) located in the upstream region of the genes. In contrast, MTF-1 binding to the MRE in vitro is induced only by zinc ions, suggesting that MTF-1 acts as a zinc sensor protein. Although the mechanism allowing such a zinc-responsive factor to respond to various metal species in vivo remains ambiguous, recent information regarding the metal response of MTF-1 and the genes expressed downstream of MTF-1 provides important clues to unraveling the intrinsic mechanism and the biological significance of the MTF-1 functions in vivo.

引用

页码：513 / 519

页数：7

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