Human Protein Reference Database-2009 update

被引：2437

作者：

Prasad, T. S. Keshava ^{[4
]}

Goel, Renu ^{[4
]}

Kandasamy, Kumaran ^{[1
,2
,3
,4
,5
]}

Keerthikumar, Shivakumar ^{[4
,5
]}

Kumar, Sameer ^{[4
,5
]}

Mathivanan, Suresh ^{[4
,5
]}

Telikicherla, Deepthi ^{[4
,5
]}

Raju, Rajesh ^{[4
,5
]}

Shafreen, Beema ^{[4
]}

Venugopal, Abhilash ^{[4
,5
]}

Balakrishnan, Lavanya ^{[4
]}

Marimuthu, Arivusudar ^{[1
,2
,3
,4
]}

Banerjee, Sutopa ^{[4
]}

Somanathan, Devi S. ^{[4
]}

Sebastian, Aimy ^{[4
]}

Rani, Sandhya ^{[4
]}

Ray, Somak ^{[4
]}

Kishore, C. J. Harrys ^{[4
]}

Kanth, Sashi ^{[4
]}

Ahmed, Mukhtar ^{[4
]}

Kashyap, Manoj K. ^{[1
,2
,3
,4
,5
]}

Mohmood, Riaz ^{[5
]}

Ramachandra, Y. L. ^{[5
]}

Krishna, V. ^{[5
]}

Rahiman, B. Abdul ^{[5
]}

Mohan, Sujatha ^{[4
]}

Ranganathan, Prathibha ^{[4
]}

Ramabadran, Subhashri ^{[4
]}

Chaerkady, Raghothama ^{[1
,2
,3
,4
]}

Pandey, Akhilesh ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Dept Biol Chem, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Pathol & Oncol, Baltimore, MD 21205 USA

[4] Int Tech Pk, Inst Bioinformat, Bangalore 560066, Karnataka, India

[5] Kuvempu Univ, Dept Biotechnol, Shankaraghatta, Karnataka, India

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

关键词：

BIOLOGICAL NETWORKS; SYSTEMS BIOLOGY; INTEGRATION; INTERACTOME; ANNOTATION; PLATFORM; MOTIFS;

D O I：

10.1093/nar/gkn892

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human Protein Reference Database (HPRD-http://www.hprd.org/), initially described in 2003, is a database of curated proteomic information pertaining to human proteins. We have recently added a number of new features in HPRD. These include PhosphoMotif Finder, which allows users to find the presence of over 320 experimentally verified phosphorylation motifs in proteins of interest. Another new feature is a protein distributed annotation system-Human Proteinpedia (http://www.humanproteinpedia.org/)-through which laboratories can submit their data, which is mapped onto protein entries in HPRD. Over 75 laboratories involved in proteomics research have already participated in this effort by submitting data for over 15 000 human proteins. The submitted data includes mass spectrometry and protein microarray-derived data, among other data types. Finally, HPRD is also linked to a compendium of human signaling pathways developed by our group, NetPath (http://www.netpath.org/), which currently contains annotations for several cancer and immune signaling pathways. Since the last update, more than 5500 new protein sequences have been added,

引用

页码：D767 / D772

页数：6

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