Where splicing joins chromatin

被引：44

作者：

Hnilicova, Jarmila ^{[1
]}

Stanek, David ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Mol Genet, Dept RNA Biol, Prague, Czech Republic

来源：

NUCLEUS | 2011年 / 2卷 / 03期

关键词：

chromatin; exon; alternative splicing; transcription; snRNP; histone methylation; histone acetylation; nucleosome; INTRON-CONTAINING GENES; IN-SITU TRANSCRIPTION; GENOME-WIDE ANALYSIS; DNA-DAMAGE; HISTONE DEACETYLASE; EXON INCLUSION; U1; SNRNP; RNA; PROMOTER; RECRUITMENT;

D O I：

10.4161/nucl.2.3.15876

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There are numerous data suggesting that two key steps in gene expression-transcription and splicing influence each other closely. For a long time it was known that chromatin modifications regulate transcription, but only recently it was shown that chromatin and histone modifications play a significant role in pre-mRNA splicing. Here we summarize interactions between splicing machinery and chromatin and discuss their potential functional significance. We focus mainly on histone acetylation and methylation and potential mechanisms of their role in splicing. It seems that whereas histone acetylation acts mainly by alterating the transcription rate, histone methylation can also influence splicing directly by recruiting various splicing components.

引用

页码：182 / 188

页数：7

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