Planar catechin analogues with alkyl side chains:: A potent antioxidant and an α-glucosidase inhibitor

被引:65
作者
Hakamata, Wataru
Nakanishio, Ikuo
Masuda, Yu
Shimizu, Takehiko
Higuchi, Hajime
Nakamura, Yuriko
Saito, Shinichi
Urano, Shiro
Oku, Tadatake
Ozawa, Toshihiko
Ikota, Nobuo
Miyata, Naoki
Okuda, Haruhiro
Fukuhara, Kiyoshi [1 ]
机构
[1] Natl Inst Hlth Sci, Div Organ Chem, Setagaya Ku, Tokyo 1588501, Japan
[2] Natl Inst Radiol Sci, Res Ctr Radiat Safety, Redox Regulat Res Grp, Inage Ku, Chiba 2638555, Japan
[3] Osaka Univ, Grad Sch Engn, Japan Sci & Technol Agcy, SORST, Suita, Osaka 5650871, Japan
[4] Nihon Univ, Coll Bioresource Sci, Fujisawa, Kanagawa 1866, Japan
[5] Shibaura Inst Technol, Dept Appl Chem, Minato Ku, Tokyo 1088548, Japan
[6] Tokyo Univ Sci, Fac Sci, Tokyo 1628601, Japan
[7] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan
关键词
D O I
10.1021/ja057763c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Planar catechin analogues having various alkyl side chain lengths were synthesized, and their remarkable antioxidative abilities and α-glucosidase inhibitory activities are shown. Copyright © 2006 American Chemical Society.
引用
收藏
页码:6524 / 6525
页数:2
相关论文
共 9 条
[1]   A planar catechin analogue as a promising antioxidant with reduced prooxidant activity [J].
Fukuhara, K ;
Nakanishi, I ;
Shimada, T ;
Ohkubo, K ;
Miyazaki, K ;
Hakamata, W ;
Urano, S ;
Ozawa, T ;
Okuda, H ;
Miyata, N ;
Ikota, N ;
Fukuzumi, S .
CHEMICAL RESEARCH IN TOXICOLOGY, 2003, 16 (01) :81-86
[2]   Enhanced radical-scavenging activity of a planar catechin analogue [J].
Fukuhara, K ;
Nakanishi, I ;
Kansui, H ;
Sugiyama, E ;
Kimura, M ;
Shimada, T ;
Urano, S ;
Yamaguchi, K ;
Miyata, N .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (21) :5952-5953
[3]  
Joe AK, 2002, CLIN CANCER RES, V8, P893
[4]   Alterations of mitochondrial DNA in common diseases and disease states: Aging, neurodegeneration, heart failure, diabetes and cancer [J].
Kang, DC ;
Hamasaki, N .
CURRENT MEDICINAL CHEMISTRY, 2005, 12 (04) :429-441
[5]  
Krasowska A, 2001, CELL MOL BIOL LETT, V6, P71
[6]   In vitro survey of alpha-glucosidase inhibitory food components [J].
Matsui, T ;
Yoshimoto, C ;
Osajima, K ;
Oki, T ;
Osajima, Y .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1996, 60 (12) :2019-2022
[7]   A planar catechin analogue having a more negative oxidation potential than (+)-catechin as an electron transfer antioxidant against a peroxyl radical [J].
Nakanishi, I ;
Ohkubo, K ;
Miyazaki, K ;
Hakamata, W ;
Urano, S ;
Ozawa, T ;
Okuda, H ;
Fukuzumi, S ;
Ikota, N ;
Fukuhara, K .
CHEMICAL RESEARCH IN TOXICOLOGY, 2004, 17 (01) :26-31
[8]   Mitochondria, oxygen free radicals, and apoptosis [J].
Raha, S ;
Robinson, BH .
AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 106 (01) :62-70
[9]  
TSIMIKAS S, 2000, OXIDATIVE STRESS VAS, P49