Loss of the Ras Regulator RASAL1: Another Route to Ras Activation in Colorectal Cancer

被引:15
作者
Bernards, Andre [1 ]
Settleman, Jeffrey [1 ]
机构
[1] Massachusetts Gen Hosp, Canc Res Ctr, Charlestown, MA 02129 USA
关键词
ABERRANT PROMOTER METHYLATION; PROTEIN HDAB2IP GENE; PROSTATE-CANCER; NOONAN-SYNDROME; MUTATIONS; TUMOR; EXPRESSION; CARCINOMA; BREAST;
D O I
10.1053/j.gastro.2008.11.024
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
引用
收藏
页码:46 / 48
页数:3
相关论文
共 23 条
[1]
The RAS/MAPK syndromes: Novel roles of the RAS pathway in human genetic disorders [J].
Aoki, Yoko ;
Niihori, Tetsuya ;
Narumi, Yoko ;
Kure, Shigeo ;
Matsubara, Yoichi .
HUMAN MUTATION, 2008, 29 (08) :992-1006
[2]
GAPs in growth factor signalling [J].
Bernards, A ;
Settleman, J .
GROWTH FACTORS, 2005, 23 (02) :143-149
[3]
GEFs in growth factor signaling [J].
Bernards, Andre ;
Settleman, Jeffrey .
GROWTH FACTORS, 2007, 25 (05) :355-361
[4]
Ras superfamily and interacting proteins database [J].
Bernards, Andre .
REGULATORS AND EFFECTORS OF SMALL GTPASES: RAS FAMILY, 2006, 407 :1-9
[5]
PREVALENCE OF RAS GENE-MUTATIONS IN HUMAN COLORECTAL CANCERS [J].
BOS, JL ;
FEARON, ER ;
HAMILTON, SR ;
VERLAANDEVRIES, M ;
VANBOOM, JH ;
VANDEREB, AJ ;
VOGELSTEIN, B .
NATURE, 1987, 327 (6120) :293-297
[6]
Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer [J].
Chen, H ;
Tu, SW ;
Hsieh, JT .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (23) :22437-22444
[7]
Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines [J].
Chen, H ;
Toyooka, S ;
Gazdar, AF ;
Hsieh, JT .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (05) :3121-3130
[8]
NF1 tumor suppressor gene function: Narrowing the GAP [J].
Cichowski, K ;
Jacks, T .
CELL, 2001, 104 (04) :593-604
[9]
Mutations of the BRAF gene in human cancer [J].
Davies, H ;
Bignell, GR ;
Cox, C ;
Stephens, P ;
Edkins, S ;
Clegg, S ;
Teague, J ;
Woffendin, H ;
Garnett, MJ ;
Bottomley, W ;
Davis, N ;
Dicks, N ;
Ewing, R ;
Floyd, Y ;
Gray, K ;
Hall, S ;
Hawes, R ;
Hughes, J ;
Kosmidou, V ;
Menzies, A ;
Mould, C ;
Parker, A ;
Stevens, C ;
Watt, S ;
Hooper, S ;
Wilson, R ;
Jayatilake, H ;
Gusterson, BA ;
Cooper, C ;
Shipley, J ;
Hargrave, D ;
Pritchard-Jones, K ;
Maitland, N ;
Chenevix-Trench, G ;
Riggins, GJ ;
Bigner, DD ;
Palmieri, G ;
Cossu, A ;
Flanagan, A ;
Nicholson, A ;
Ho, JWC ;
Leung, SY ;
Yuen, ST ;
Weber, BL ;
Siegler, HF ;
Darrow, TL ;
Paterson, H ;
Marais, R ;
Marshall, CJ ;
Wooster, R .
NATURE, 2002, 417 (6892) :949-954
[10]
Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer [J].
Dote, H ;
Toyooka, S ;
Tsukuda, K ;
Yano, M ;
Ouchida, M ;
Doihara, H ;
Suzuki, M ;
Chen, H ;
Hsieh, JT ;
Gazdar, AF ;
Shimizu, N .
CLINICAL CANCER RESEARCH, 2004, 10 (06) :2082-2089