Infrared analysis of bone in health and disease

被引：132

作者：

Boskey, A

Mendelsohn, R

机构：

[1] Cornell Univ, Weill Med Coll, Musculoskeletal Inetgr Program, Hosp Special Surg, New York, NY 10021 USA

[2] Cornell Univ, Weill Med Coll, Program Physiol Biophys & Syst Biol, New York, NY 10021 USA

[3] Rutgers State Univ, Dept Chem, Newark, NJ 07102 USA

[4] Rutgers State Univ, Program Appl Phys, Newark, NJ 07102 USA

[5] Rutgers State Univ, Program Biol Sci, Newark, NJ 07102 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2005年 / 10卷 / 03期

关键词：

bone; hydroxyapatite; collagen; infrared microspectroscopy; infrared microspectroscopic imaging;

D O I：

10.1117/1.1922927

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Infrared spectroscopy, microspectroscopy, and microspectroscopic imaging have been used to probe the composition and physicochemical status of mineral and matrix of bone in normal and diseased tissues using a series of validated parameters that reflect quantitative and qualitative properties. In this review, emphasis is placed on changes in bone's composition and physiochemical status during osteoporosis and the impact of currently used therapeutics on these parameters, although the impact of infrared microscopy in other pathological states is briefly discussed. (c) 2005 Society of Photo-Optical Instrumentation Engineers.

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页数：9

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