共 22 条
Time to metastatic relapse and breast cancer cells dissemination in bone marrow at metastatic relapse
被引:12
作者:

Bidard, Francois-Clement
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Inst Curie, Dept Med Oncol, F-75005 Paris, France Inst Curie, Dept Med Oncol, F-75005 Paris, France

Vincent-Salomon, Anne
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Inst Curie, Dept Pathol, F-75005 Paris, France Inst Curie, Dept Med Oncol, F-75005 Paris, France

Sigal-Zafrani, Brigitte
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Inst Curie, Dept Pathol, F-75005 Paris, France Inst Curie, Dept Med Oncol, F-75005 Paris, France

Rodrigues, Manuel
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Inst Curie, Dept Med Oncol, F-75005 Paris, France Inst Curie, Dept Med Oncol, F-75005 Paris, France

Dieras, Veronique
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机构:
Inst Curie, Dept Med Oncol, F-75005 Paris, France Inst Curie, Dept Med Oncol, F-75005 Paris, France

Mignot, Laurent
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h-index: 0
机构:
Inst Curie, Dept Med Oncol, F-75005 Paris, France Inst Curie, Dept Med Oncol, F-75005 Paris, France

Sastre-Garau, Xavier
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机构:
Inst Curie, Dept Pathol, F-75005 Paris, France Inst Curie, Dept Med Oncol, F-75005 Paris, France

Poupon, Marie-France
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机构:
Inst Curie, Dept Translat Res, F-75005 Paris, France Inst Curie, Dept Med Oncol, F-75005 Paris, France

Pierga, Jean-Yves
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h-index: 0
机构:
Inst Curie, Dept Med Oncol, F-75005 Paris, France
Univ Paris 05, Paris, France Inst Curie, Dept Med Oncol, F-75005 Paris, France
机构:
[1] Inst Curie, Dept Med Oncol, F-75005 Paris, France
[2] Inst Curie, Dept Pathol, F-75005 Paris, France
[3] Inst Curie, Dept Translat Res, F-75005 Paris, France
[4] Univ Paris 05, Paris, France
关键词:
Disseminated tumor cells;
Bone marrow;
Micrometastasis;
Metastasis;
Breast cancer;
D O I:
10.1007/s10585-008-9203-1
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Breast cancer dissemination can be monitored in patients by detecting circulating and/or disseminated tumor cells. However, bone marrow disseminated tumor cells (BM DTC) may undergo a dormancy during several years before growing (or not) into clinically detectable metastases. We therefore hypothesized that breast cancers which have formed BM DTC in the course of their metastatic growth might exhibit a longer interval before metastatic relapse. We examined the association of DTC detection (cytokeratin 8, 18 or 19 positive epithelial cells with cancerous morphological features), at metastatic relapse, with the metastasis-free interval in breast cancer patients. In the 110 metastatic patients studied, 42% (n = 64/110) were classified as BM DTC-negative. These patients had a significantly shorter metastasis-free interval than BM DTC-positive patients (P = 0.02). In multivariate logistic regression analysis, the metastasis-free interval was an independent predictor of DTC detection (P = 0.02), together with bone metastasis (P = 0.0003) and low tumor grade (grade I or II, P = 0.05). We finally suggest that a faster metastatic process might skip in some patients the BM DTC-associated dormancy step. Dissemination of DTC in other host organ and/or epithelial-mesenchymal transition from cytokeratin-positive to cytokeratin-negative DTC may explain this observation.
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页码:871 / 875
页数:5
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NCI, Ctr Canc Res, Lab Mol Pharmacol, Womens Canc Sect,NIH, Bethesda, MD 20892 USA NCI, Ctr Canc Res, Lab Mol Pharmacol, Womens Canc Sect,NIH, Bethesda, MD 20892 USA
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Vincent-Salomon, A.
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h-index: 0
机构:
Inst Curie, Dept Pathol, F-75248 Paris 05, France Inst Curie, Dept Pathol, F-75248 Paris 05, France

Bidard, F. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Curie, Dept Pathol, F-75248 Paris 05, France Inst Curie, Dept Pathol, F-75248 Paris 05, France

Pierga, J. Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Curie, Dept Pathol, F-75248 Paris 05, France Inst Curie, Dept Pathol, F-75248 Paris 05, France
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Wiedswang, G
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h-index: 0
机构: Ulleval Univ Clin, Dept Surg, Oslo, Norway

Borgen, E
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h-index: 0
机构: Ulleval Univ Clin, Dept Surg, Oslo, Norway

Karesen, R
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h-index: 0
机构: Ulleval Univ Clin, Dept Surg, Oslo, Norway

Kvalheim, G
论文数: 0 引用数: 0
h-index: 0
机构: Ulleval Univ Clin, Dept Surg, Oslo, Norway

Nesland, JM
论文数: 0 引用数: 0
h-index: 0
机构: Ulleval Univ Clin, Dept Surg, Oslo, Norway

Schlichting, HQE
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h-index: 0
机构: Ulleval Univ Clin, Dept Surg, Oslo, Norway

Sauer, T
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h-index: 0
机构: Ulleval Univ Clin, Dept Surg, Oslo, Norway

Janbu, J
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h-index: 0
机构: Ulleval Univ Clin, Dept Surg, Oslo, Norway

Harbitz, T
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h-index: 0
机构: Ulleval Univ Clin, Dept Surg, Oslo, Norway

Naume, B
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h-index: 0
机构: Ulleval Univ Clin, Dept Surg, Oslo, Norway