Polyacrylic Acid Functionalized Nanographene as a Nanocarrier for Loading and Controlled Release of Doxorubicin Hydrochloride

被引：24

作者：

Chen, Yunping ^{[1
]}

Qi, Yuanyuan ^{[1
]}

Liu, Bin ^{[1
]}

机构：

[1] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF NANOMATERIALS | 2013年 / 2013卷

关键词：

FEW-LAYERED GRAPHENE; NANO-GRAPHENE; THERMAL-STABILITY; FACILE SYNTHESIS; DRUG; DELIVERY; OXIDE; PH; NANOTECHNOLOGY; OPPORTUNITIES;

D O I：

10.1155/2013/345738

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Graphene nanosheets (GNSs) were synthesized by direct current arc discharge and subsequently functionalized by highly hydrophilic polyacrylic acid (PAA). The loading and release of doxorubicin hydrochloride (DOX) on PAA-functionalized GNSs (PAA-GNSs) were investigated. PAA-GNSs were successfully prepared and verified by atomic force microscope (AFM), Fourier-transform infrared (FTIR) and ultraviolet-visible (UV-vis) spectroscopes, and thermogravimetric analysis (TGA). The PAA-GNSs contained about 10 wt% PAA which significantly improved the solubility of GNSs in aqueous media. The efficient loading of DOX onto the PAA-GNSs is as high as 2.404 +/- 0.167 mg/mg at the DOX concentration of 0.36 mg/mL. Furthermore, the PPA-GNSs showed strong pH-dependent behavior and efficient slow release ability. Therefore, PAA-GNSs are promising new materials for biological and medical applications.

引用

页数：8

共 45 条

[1]

Honeycomb Carbon: A Review of Graphene [J].