Periodontal infections and coronary heart disease - Role of periodontal bacteria and importance of total pathogen burden in the coronary event and periodontal disease (CORODONT) study
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作者:
Spahr, A
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机构:Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89081 Ulm, Germany
Spahr, A
Klein, E
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机构:Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89081 Ulm, Germany
Klein, E
Khuseyinova, N
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机构:Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89081 Ulm, Germany
Khuseyinova, N
Boeckh, C
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机构:Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89081 Ulm, Germany
Boeckh, C
Muche, R
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机构:Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89081 Ulm, Germany
Muche, R
Kunze, M
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机构:Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89081 Ulm, Germany
Kunze, M
Rothenbacher, D
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机构:Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89081 Ulm, Germany
Rothenbacher, D
Pezeshki, G
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机构:Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89081 Ulm, Germany
Pezeshki, G
Hoffmeister, A
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机构:Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89081 Ulm, Germany
Hoffmeister, A
Koenig, W
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机构:Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89081 Ulm, Germany
Koenig, W
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[1] Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89081 Ulm, Germany
Background: Chronic inflammation from any source is associated with increased cardiovascular risk. Periodontitis is a possible trigger of chronic inflammation. We investigated the possible association between periodontitis and coronary heart disease (CHD), focusing on microbiological aspects. Methods: A total of 789 subjects ( 263 patients with angiographically confirmed, stable CHD and 526 population-based, age- and sex-matched controls without a history of CHD) were included in the Coronary Event and Periodontal Disease (CORODONT) study. Subgingival biofilm samples were analyzed for periodontal pathogens Actinobacillus actinomycetemcomitans, Tannerella forsythensis, Porphyromonas gingivalis, Prevotella intermedia, and Treponema denticola using DNA-DNA hybridization. The need for periodontal treatment in each subject was assessed using the Community Periodontal Index of Treatment Needs ( CPITN). The main outcome measures included total periodontal pathogen burden, number of the various periodontal pathogens in the subgingival biofilm, and periodontal treatment needs ( according to the CPITN). Results: In multivariable analyses, we found a statistically significant association between the periodontal pathogen burden ( log(10) of the sum of all pathogens) ( odds ratio [ OR], 1.92; 95% confidence interval [CI], 1.34-2.74; P <. 001) or the number of A actinomycetemcomitans in periodontal pockets ( log10) ( OR, 2.70; 95% CI, 1.79- 4.07; P <. 001) and the presence of CHD. In addition, a statistically significant association between an increase in mean CPITN score by 1 and the presence of CHD ( OR, 1.67; 95% CI, 1.08-2.58; P=.02) was observed. Conclusions: Our findings suggest an association between periodontitis and presence of CHD. Periodontal pathogen burden, and particularly infection with A actinomycetemcomitans, may be of special importance.
机构:
Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA
Kullo, IJ
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Gau, GT
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Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA
Gau, GT
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Tajik, AJ
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Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA
机构:
Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA
Kullo, IJ
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Gau, GT
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机构:
Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA
Gau, GT
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Tajik, AJ
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机构:
Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA