Engineering the mouse genome by site-specific recombination

被引：92

作者：

Metzger, D

Feil, R

机构：

[1] Coll France, ULP, CNRS, INSERM,Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

[2] Tech Univ Munich, Inst Pharmakol & Toxikol, D-80802 Munich, Germany

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0958-1669(99)00012-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Site-specific recombination systems are powerful tools for introducing predetermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled manner in mice, offering unprecedented possibilities for studying mammalian genome function and for generating animal models for human diseases.

引用

页码：470 / 476

页数：7

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