Engineering the mouse genome by site-specific recombination

被引：92

作者：

Metzger, D

Feil, R

机构：

[1] Coll France, ULP, CNRS, INSERM,Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

[2] Tech Univ Munich, Inst Pharmakol & Toxikol, D-80802 Munich, Germany

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0958-1669(99)00012-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Site-specific recombination systems are powerful tools for introducing predetermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled manner in mice, offering unprecedented possibilities for studying mammalian genome function and for generating animal models for human diseases.

引用

收藏

页码：470 / 476

页数：7

相关论文

共 78 条

[61] Temporally and spatially regulated somatic mutagenesis in mice [J].

Schwenk, F ;

Kühn, R ;

Angrand, PO ;

Rajewsky, K ;

Stewart, AF .

NUCLEIC ACIDS RESEARCH, 1998, 26 (06) :1427-1432

[62] Efficient BLG-Cre mediated gene deletion in the mammary gland [J].

Selbert, S ;

Bentley, DJ ;

Melton, DW ;

Rannie, D ;

Lourenço, P ;

Watson, CJ ;

Clarke, AR .

TRANSGENIC RESEARCH, 1998, 7 (05) :387-396

[63] Rapid colorectal adenoma formation initiated by conditional targeting of the APC gene [J].

Shibata, H ;

Toyama, K ;

Shioya, H ;

Ito, M ;

Hirota, M ;

Hasegawa, S ;

Matsumoto, H ;

Takano, H ;

Akiyama, T ;

Toyoshima, K ;

Kanamaru, R ;

Kanegae, Y ;

Saito, I ;

Nakamura, Y ;

Shiba, K ;

Noda, H .

SCIENCE, 1997, 278 (5335) :120-123

[64] A SITE-DIRECTED CHROMOSOMAL TRANSLOCATION INDUCED IN EMBRYONIC STEM-CELLS BY CRE-LOXP RECOMBINATION [J].

SMITH, AJH ;

DESOUSA, MA ;

KWABIADDO, B ;

HEPPELLPARTON, A ;

IMPEY, H ;

RABBITTS, P .

NATURE GENETICS, 1995, 9 (04) :376-385

[65] Generalized lacZ expression with the ROSA26 Cre reporter strain [J].

Soriano, P .

NATURE GENETICS, 1999, 21 (01) :70-71

[66] Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter [J].

StOnge, L ;

Furth, PA ;

Gruss, P .

NUCLEIC ACIDS RESEARCH, 1996, 24 (19) :3875-3877

[67]

Stricklett PK, 1998, GENE, V215, P415

[68] Effects of altered gene order or orientation of the locus control region on human β-globin gene expression in mice [J].

Tanimoto, K ;

Liu, QH ;

Bungert, J ;

Engel, JD .

NATURE, 1999, 398 (6725) :344-348

[69] Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development [J].

Tarutani, M ;

Itami, S ;

Okabe, M ;

Ikawa, M ;

Tezuka, T ;

Yoshikawa, K ;

Kinoshita, T ;

Takeda, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (14) :7400-7405

[70]

Torres RM, 1997, LAB PROTOCOLS CONDIT

← 1 2 3 4 5 6 7 8 →