Protein tyrosine phosphatase 1B inhibitors from Morus root bark

被引：134

作者：

Cui, L

Na, MK

Oh, M

Bae, EY

Jeong, DG

Ryu, SE

Kim, S

Kim, BY

Oh, WK

Ahn, JS

机构：

[1] KRIBB, Taejon 305333, South Korea

[2] Silla Univ, MCBI, Pusan 617736, South Korea

[3] Silla Univ, Coll Nat Sci, Pusan 617736, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 05期

关键词：

Morus root bark; protein tyrosine phosphatase 1B; sanggenon C; sanggenon G; mulberrofuran C; kuwanon L;

D O I：

10.1016/j.bmcl.2005.11.071

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An organic layer prepared from the Chinese crude drug 'Sang-Bai-Pi' (Morus root bark) was studied in order to identify the inhibitory compounds for protein tyrosine phosphatase 1B (PTP1B). Bioassay-guided fractionation resulted in the isolation of sanggenon C (1), sanggenon G (2), mulberrofuran C (3) and kuwanon L (4) as PTP1B inhibitors, along with moracin O (5) and moracin P (6). Compounds 1-4 inhibited PTP1B with IC50 values ranging from 1.6 +/- 0.3 mu M to 16.9 +/- 1.1 mu M. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1426 / 1429

页数：4

共 25 条

[21] STRUCTURE OF SANGGENON-C, A NATURAL HYPOTENSIVE DIELS-ALDER ADDUCT FROM CHINESE CRUDE DRUG SANG-BAI-PI (MORUS ROOT BARKS) [J].