New strategies for the synthesis of pyrimidine derivatives

被引：140

作者：

Hill, Matthew D.

Movassaghi, Mohammad

机构：

[1] Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, 77 Massachusetts Ave.

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 23期

关键词：

amides; condensation; cyclization; heterocycles; pyrimidine;

D O I：

10.1002/chem.200800014

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent advances in pyrimidine synthesis are described. Modification of conventional strategies involving N-C-N fragment condensation with 1,3-dicarbonyl derivatives remains a common theme in current literature. Other methods. including N-C fragment condensation strategies, provide reactive intermediates capable of intramolecular cyclization and formation of pyrimidine derivatives. These recently developed methodologies offer a valuable addendum to azaheterocycle synthesis.

引用

页码：6836 / 6844

页数：9

共 51 条

[1] Practical routes to diacetylenic ketones and their application for the preparation of alkynyl substituted pyridines, pyrimidines and pyrazoles [J].

Adamo, MFA ;

Adlington, RM ;

Baldwin, JE ;

Pritchard, GJ ;

Rathmell, RE .

TETRAHEDRON, 2003, 59 (13) :2197-2205

[2]

Baran PS, 2006, HETEROCYCLES, V70, P581

[3] Synthesis of 4-(3-hydroxyalkyl)pyrimidines by ring transformation reactions of 2-alkylidenetetrahydrofurans with amidines [J].

Bellur, Esen ;

Langer, Peter .

TETRAHEDRON, 2006, 62 (23) :5426-5434

[4] Highly efficient monophosphine-based catalyst for the palladium-catalyzed Suzuki-Miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters [J].

Billingsley, Kelvin ;

Buchwald, Stephen L. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (11) :3358-3366

[5] The role of capecitabine, an oral, enzymatically activated fluoropyrimidine, in the treatment of metastatic breast cancer [J].

Blum, JL .

ONCOLOGIST, 2001, 6 (01) :56-64

[6]

Bose DS, 1999, SYNTHESIS-STUTTGART, P64

[7]

Brugnatelli G, 1818, Giornale di fisica, chimica, et storiaNaturale (Pavia) decada seconda, V1, P117

[8]

Brugnatelli L., 1818, ANN CHIM PHYS, V8, P201

[9] Spectroscopic studies of the electrophilic activation of amides with triflic anhydride and pyridine [J].

Charette, AB ;

Grenon, M .

CANADIAN JOURNAL OF CHEMISTRY, 2001, 79 (11) :1694-1703

[10] Metalated heterocycles and their applications in synthetic organic chemistry [J].

Chinchilla, R ;

Nájera, C ;

Yus, M .

CHEMICAL REVIEWS, 2004, 104 (05) :2667-2722

← 1 2 3 4 5 6 →