Practical routes to diacetylenic ketones and their application for the preparation of alkynyl substituted pyridines, pyrimidines and pyrazoles

被引：46

作者：

Adamo, MFA

Adlington, RM

Baldwin, JE

Pritchard, GJ

Rathmell, RE

机构：

[1] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

TETRAHEDRON | 2003年 / 59卷 / 13期

关键词：

heterocycle; pyrimidine; pyrazoles;

D O I：

10.1016/S0040-4020(03)00244-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkynyl substituted pyridines, pyrimidines and pyrazoles have been synthesised by cyclocondensations of diacetylenic ketones with enamines, amidines and hydrazines, respectively. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2197 / 2205

页数：9

共 29 条

[1] A versatile synthetic route to quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls
Adlington, RM
Baldwin, JE
Catterick, D
Pritchard, GJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (03): : 299 - 302
[2] The synthesis of novel heterocyclic substituted α-amino acids;: further exploitation of α-amino acid alkynyl ketones as reactive substrates
Adlington, RM
Baldwin, JE
Catterick, D
Pritchard, GJ
Tang, LT
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (15): : 2311 - 2316
[3] The efficient, enantioselective synthesis of quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls
Adlington, RM
Baldwin, JE
Catterick, D
Pritchard, GJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2001, (07): : 668 - 679
[4] The synthesis of novel heterocyclic substituted α-amino acids;: further exploitation of α-amino acid alkynyl ketones
Adlington, RM
Baldwin, JE
Catterick, D
Pritchard, GJ
Tang, LT
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (03): : 303 - 305
[5] The synthesis of pyrimidin-4-yl substituted α-amino acids.: A versatile approach from alkynyl ketones
Adlington, RM
Baldwin, JE
Catterick, D
Pritchard, GJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (08): : 855 - 866
[6] Synthesis of novel C-nucleosides with potential applications in combinatorial and parallel synthesis
Adlington, RM
Baldwin, JE
Pritchard, GJ
Spencer, KC
[J]. TETRAHEDRON LETTERS, 2000, 41 (04) : 575 - 578
[7] ADLINGTON RM, 1997, J CHEM SOC CHEM COMM, P1757
[8] Novel C-4 heteroaromatic kainoid analogues: A parallel synthesis approach
Baldwin, JE
Fryer, AM
Pritchard, GJ
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (03) : 309 - 311
[9] The synthesis of 4-arylsulfanyl-substituted kainoid analogues from trans-4-hydroxy-L-proline
Baldwin, JE
Pritchard, GJ
Williamson, DS
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (17) : 1927 - 1929
[10] The reactions of diacetylenic ketones with nitrogen nucleophiles; facile preparation of alkynyl substituted pyrimidines and pyrazoles
Baldwin, JE
Pritchard, GJ
Rathmell, RE
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2001, (22): : 2906 - 2908

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