The reactions of diacetylenic ketones with nitrogen nucleophiles; facile preparation of alkynyl substituted pyrimidines and pyrazoles

被引：45

作者：

Baldwin, JE

Pritchard, GJ

Rathmell, RE

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 22期

关键词：

D O I：

10.1039/b108645f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkynyl substituted pyrimidines and pyrazoles have been synthesized by cyclocondensations of diacetylenic ketones with amidines and hydrazines.

引用

页码：2906 / 2908

页数：3

共 16 条

[1] A versatile synthetic route to quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls
Adlington, RM
Baldwin, JE
Catterick, D
Pritchard, GJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (03): : 299 - 302
[2] The synthesis of novel heterocyclic substituted α-amino acids;: further exploitation of α-amino acid alkynyl ketones as reactive substrates
Adlington, RM
Baldwin, JE
Catterick, D
Pritchard, GJ
Tang, LT
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (15): : 2311 - 2316
[3] The efficient, enantioselective synthesis of quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls
Adlington, RM
Baldwin, JE
Catterick, D
Pritchard, GJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2001, (07): : 668 - 679
[4] The synthesis of novel heterocyclic substituted α-amino acids;: further exploitation of α-amino acid alkynyl ketones
Adlington, RM
Baldwin, JE
Catterick, D
Pritchard, GJ
Tang, LT
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (03): : 303 - 305
[5] The synthesis of pyrimidin-4-yl substituted α-amino acids.: A versatile approach from alkynyl ketones
Adlington, RM
Baldwin, JE
Catterick, D
Pritchard, GJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (08): : 855 - 866
[6] Synthesis of novel C-nucleosides with potential applications in combinatorial and parallel synthesis
Adlington, RM
Baldwin, JE
Pritchard, GJ
Spencer, KC
[J]. TETRAHEDRON LETTERS, 2000, 41 (04) : 575 - 578
[7] ADLINGTON RM, 1997, J CHEM SOC CHEM COMM, P1757
[8] Novel C-4 heteroaromatic kainoid analogues: A parallel synthesis approach
Baldwin, JE
Fryer, AM
Pritchard, GJ
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (03) : 309 - 311
[9] The synthesis of 4-arylsulfanyl-substituted kainoid analogues from trans-4-hydroxy-L-proline
Baldwin, JE
Pritchard, GJ
Williamson, DS
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (17) : 1927 - 1929
[10] Synthesis of novel unsymmetrical and symmetrical diacetylenic ketones.
Baldwin, JE
Pritchard, GJ
Rathmell, RE
[J]. SYNTHETIC COMMUNICATIONS, 2000, 30 (21) : 3833 - 3847

← 1 2 →