Structure and functions of eukaryotic nuclear DNA-dependent RNA polymerase I

被引：7

作者：

Shematorova, EK ^{[1
]}

Shpakovski, GV ^{[1
]}

机构：

[1] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

MOLECULAR BIOLOGY | 2002年 / 36卷 / 01期

关键词：

nucleolar RNA polymerase; subunit composition; rDNA regulatory elements; transcription factors; RNA polymerase I;

D O I：

10.1023/A:1014202519609

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the eukaryotic cell, normal protein biosynthesis is sustained by several million ribosomes, which contain rRNA as an essential component. The high-molecular-weight precursor of large and 5.8S rRNAs is synthesized by DNA-dependent RNA polymerase I (Pol I) in the nucleolus. Data on DNA regulatory elements, protein factors involved in rDNA transcription by Pol I, subunit composition of Pol I, and on the interactions and possible functions of individual subunits are summarized.

引用

页码：1 / 17

页数：17

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