Structure and functions of eukaryotic nuclear DNA-dependent RNA polymerase I

被引：7

作者：

Shematorova, EK ^{[1
]}

Shpakovski, GV ^{[1
]}

机构：

[1] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

MOLECULAR BIOLOGY | 2002年 / 36卷 / 01期

关键词：

nucleolar RNA polymerase; subunit composition; rDNA regulatory elements; transcription factors; RNA polymerase I;

D O I：

10.1023/A:1014202519609

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the eukaryotic cell, normal protein biosynthesis is sustained by several million ribosomes, which contain rRNA as an essential component. The high-molecular-weight precursor of large and 5.8S rRNAs is synthesized by DNA-dependent RNA polymerase I (Pol I) in the nucleolus. Data on DNA regulatory elements, protein factors involved in rDNA transcription by Pol I, subunit composition of Pol I, and on the interactions and possible functions of individual subunits are summarized.

引用

页码：1 / 17

页数：17

共 195 条

[61] MAPPING AND SEQUENCING OF MUTATIONS IN THE ESCHERICHIA-COLI RPOB GENE THAT LEAD TO RIFAMPICIN RESISTANCE [J].

JIN, DJ ;

GROSS, CA .

JOURNAL OF MOLECULAR BIOLOGY, 1988, 202 (01) :45-58

[62] REB1, A YEAST DNA-BINDING PROTEIN WITH MANY TARGETS, IS ESSENTIAL FOR CELL-GROWTH AND BEARS SOME RESEMBLANCE TO THE ONCOGENE MYB [J].

JU, QD ;

MORROW, BE ;

WARNER, JR .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (10) :5226-5234

[63] BLOCKING OF THE INITIATION-TO-ELONGATION TRANSITION BY A TRANSDOMINANT RNA-POLYMERASE MUTATION [J].

KASHLEV, M ;

LEE, JY ;

ZALENSKAYA, K ;

NIKIFOROV, V ;

GOLDFARB, A .

SCIENCE, 1990, 248 (4958) :1006-1009

[64] ANIMAL DNA-DEPENDENT RNA POLYMERASES - MOLECULAR-STRUCTURES AND IMMUNOLOGICAL PROPERTIES OF CALF-THYMUS ENZYME-AI AND OF CALF-THYMUS AND RAT-LIVER ENZYMES-B [J].

KEDINGER, C ;

GISSINGER, F ;

CHAMBON, P .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1974, 44 (02) :421-436

[65] Reconstitution of yeast RNA polymerase I transcription in vitro from purified components -: TATA binding protein is not required for basal transcription [J].

Keener, J ;

Josaitis, CA ;

Dodd, JA ;

Nomura, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (50) :33795-33802

[66] Histones H3 and H4 are components of upstream activation factor required for the high-level transcription of yeast rDNA by RNA polymerase I [J].

Keener, J ;

Dodd, JA ;

Lalo, D ;

Nomura, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13458-13462

[67]

KELLY S, 1990, J BIOL CHEM, V265, P7787

[68] RRN6 AND RRN7 ENCODE SUBUNITS OF A MULTIPROTEIN COMPLEX ESSENTIAL FOR THE INITIATION OF RDNA TRANSCRIPTION BY RNA-POLYMERASE-I IN SACCHAROMYCES-CEREVISIAE [J].

KEYS, DA ;

VU, LA ;

STEFFAN, LS ;

DODD, JA ;

YAMAMOTO, RT ;

NOGI, Y ;

NOMURA, M .

GENES & DEVELOPMENT, 1994, 8 (19) :2349-2362

[69] Multiprotein transcription factor UAF interacts with the upstream element of the yeast RNA polymerase I promoter and forms a stable preinitiation complex [J].

Keys, DA ;

Lee, BS ;

Dodd, JA ;

Nguyen, TT ;

Vu, L ;

Fantino, E ;

Burson, LM ;

Nogi, Y ;

Nomura, M .

GENES & DEVELOPMENT, 1996, 10 (07) :887-903

[70] Localization of yeast RNA polymerase I core subunits by immunoelectron microscopy [J].

Klinger, C ;

Huet, J ;

Song, DY ;

Petersen, G ;

Riva, M ;

Bautz, EKF ;

Sentenac, A ;

Oudet, P ;

Schultz, P .

EMBO JOURNAL, 1996, 15 (17) :4643-4653

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