Polymerisation resistant synthesis of methacrylamido phenylboronic acids

被引：22

作者：

D'Hooge, Francois ^{[1
]}

Rogalle, Damien ^{[1
]}

Thatcher, Michael J. ^{[2
]}

Perera, Semali P. ^{[3
]}

van den Elsen, Jean M. H. ^{[4
]}

Jenkins, A. Toby A. ^{[1
]}

James, Tony D. ^{[1
]}

Fossey, John S. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Smart Holograms Ltd, Cambridge CB4 0WF, England

[3] Univ Bath, Dept Chem Engn, Bath BA2 7AY, Avon, England

[4] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

POLYMER | 2008年 / 49卷 / 16期

关键词：

boronic acid; acrylamide; deprotection;

D O I：

10.1016/j.polymer.2008.05.039

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Acrylamido boronic acids are important building blocks for functional polymers but suffer from poor synthetic strategies and unwanted polymerisation. A two-step deprotection of pinacolato methacrylamido phenylene boronic esters to generate 2-, 3- and 4-methacrylamido phenylboronic acids in good yield and purity is reported. Boronic acid containing methacrylamido monomers are now available in good yields for incorporation into polymers. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3362 / 3365

页数：4

共 21 条

[1] Targeting normal and neoplastic tissues in the rat jejunum and colon with boronated, cationic acrylamide copolymers [J].