Structural and concentration effects on the deposition of tricyclic antidepressants in human hair

被引:38
作者
Pragst, F
Rothe, M
Hunger, J
Thor, S
机构
关键词
hair analysis; tricyclic antidepressants; compliance analysis;
D O I
10.1016/S0379-0738(96)02066-X
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
In order to elucidate the possibility of a long-term compliance analysis the hair samples of 56 patients, who were under a permanent treatment with tricyclic antidepressants, were analyzed for amitriptyline, clomipramine, doxepine, imipramine and maprotiline as well as their nor-metabolites. The hair concentrations varied between 0.4 and 40 ng/mg with no strong difference between the five drugs. In comparison to the therapeutic plasma levels described in literature the nor-metabolites always accumulate less in hair than drugs. No correlation was found between the hair concentration and the daily dose. The investigation of the full hair length in 3-cm sections for several examples of all five drugs shows that they can be detected in normally kept hair at least 1 year after intake. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:225 / 236
页数:12
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