Does measurement of oxidative damage to DNA have clinical significance?

被引：193

作者：

Cooke, MS ^{[1
]}

Olinski, R

Evans, MD

机构：

[1] Univ Leicester, Leicester Royal Infirm, Univ Hosp Leicester NHS Trust, Radiat & Oxidat Stress Grp,Dept Canc Studies & Mo, Leicester LE2 7LX, Leics, England

[2] Univ Leicester, Leicester Royal Infirm, Univ Hosp Leicester NHS Trust, Dept Genet, Leicester LE2 7LX, Leics, England

[3] Nicholas Copernicus Univ, Coll Med Bydgoszcz, Dept Clin Biochem, PL-85092 Bydgoszcz, Poland

来源：

CLINICA CHIMICA ACTA | 2006年 / 365卷 / 1-2期

关键词：

DNA damage; disease; reactive oxygen species; DNA repair;

D O I：

10.1016/j.cca.2005.09.009

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Oxidative damage to DNA is the seemingly inevitable consequence of cellular metabolism. Furthermore, despite protective mechanisms, cellular levels of damage may increase under conditions of oxidative stress, arising from exposure to a variety of physical or chemical insults. Elevated levels of oxidatively damaged DNA have been measured in numerous diseases, and as a result, it has been hypothesised that such damage plays an integral role in the aetiology of that disease. This review examines the validity of this hypothesis, exploring the mechanisms by which oxidative DNA damage may lead to disease. We conclude that further validation of biomarkers of oxidative DNA damage, along with further elucidation of the role of damage in disease, may allow these biomarkers to become potentially useful clinical tools. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：30 / 49

页数：20

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