Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors.

被引：25

作者：

Noteberg, D

Branalt, J

Kvarnstrom, I

Classon, B

Samuelsson, B

Nillroth, U

Danielson, H

Karlen, A

Hallberg, A

机构：

[1] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN

[2] LINKOPING UNIV,DEPT CHEM,S-58183 LINKOPING,SWEDEN

[3] UNIV UPPSALA,DEPT BIOCHEM,S-75123 UPPSALA,SWEDEN

[4] UNIV UPPSALA,DEPT ORGAN PHARMACEUT CHEM,S-75123 UPPSALA,SWEDEN

[5] AB HASSLE,S-43183 MOLNDAL,SWEDEN

来源：

TETRAHEDRON | 1997年 / 53卷 / 23期

关键词：

D O I：

10.1016/S0040-4020(97)00482-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the four diastereomeric 2-aminocyclopentanecarboxylic acids, their use as replacements for proline in potential HIV protease inhibitors containing a hydroxyethylamine dipeptide isostere and the evaluation of the biological activity of these is described. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：7975 / 7984

页数：10

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