Cancer Modeling in the modern era: Progress and challenges

被引:249
作者
Van Dyke, T [1 ]
Jacks, T
机构
[1] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
[3] Howard Hughes Med Inst, Ctr Canc, Cambridge, MA 02139 USA
关键词
D O I
10.1016/S0092-8674(02)00621-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Genetically engineered mouse models have contributed extensively to the field of cancer research. The ability to manipulate the mouse germline affords numerous approaches toward understanding the complexities of this disease, possibly providing accurate preclinical models for therapeutic and diagnostic advances. This review highlights some of the current strategies for modeling cancer in the mouse, recent accomplishments, and key remaining challenges.
引用
收藏
页码:135 / 144
页数:10
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