Dysfunctions at human intestinal barrier by water-borne protozoan parasites: lessons from cultured human fully differentiated colon cancer cell lines

被引：10

作者：

Lievin-Le Moal, Vanessa ^{[1
,2
]}

机构：

[1] Fac Pharm Chatenay Malabry, CNRS, UMR BioCIS 8076, Team Antiparasit Chemotherapy, F-92296 Chatenay Malabry, France

[2] Univ Paris Sud, Fac Pharm, F-92296 Chatenay Malabry, France

来源：

CELLULAR MICROBIOLOGY | 2013年 / 15卷 / 06期

关键词：

CRYPTOSPORIDIUM-PARVUM INFECTION; HISTOLYTICA CYSTEINE PROTEINASE; EXPRESSING HIGH-LEVELS; NITRIC-OXIDE SYNTHASE; IN-VITRO MODEL; ENTAMOEBA-HISTOLYTICA; EPITHELIAL-CELLS; GIARDIA-DUODENALIS; ENTEROCYTIC DIFFERENTIATION; GOBLET CELLS;

D O I：

10.1111/cmi.12126

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Some water-borne protozoan parasites induce diseases through their membrane-associated functional structures and virulence factors that hijack the host cellular molecules and signalling pathways leading to structural and functional lesions in the intestinal barrier. In this Microreview we analyse the insights on the mechanisms of pathogenesis of Entamoeba intestinalis, Giardia and Cryptosporidium observed in the human colon carcinoma fully differentiated colon cancer cell lines, cell subpopulations and clones expressing the structural and functional characteristics of highly specialized fully differentiated epithelial cells lining the intestinal epithelium and mimicking structurally and functionally an intestinal barrier.

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收藏

页码：860 / 869

页数：10

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